Association of the interleukin (IL)-16 gene polymorphisms with Graves' disease

被引：41
作者：
Gu, Xue-Jiang [1 ,2 ,3 ,4 ]
Cui, Bin [1 ,2 ,3 ]
Zhao, Ze-Fei [3 ]
Chen, Hao-Yan [1 ,2 ,3 ]
Li, Xiao-Ying [1 ,2 ,3 ,5 ]
Wang, Shu [1 ,2 ,3 ]
Ning, Guang [1 ,2 ,3 ,5 ]
Zhao, Yong-Ju [3 ]
机构：
[1] Shanghai Jiao Tong Univ, Sch Med, Lab Endocrine & Metab Dis, Inst Hlth Sci, Shanghai 200025, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai 200025, Peoples R China
[3] Shanghai Jiao Tong Univ, Sch Med, Shanghai Clin Ctr Endocrine & Metab Dis,Ruijin Ho, Shanghai Inst Endocrinol & Metab,Shanghai Key Lab, Shanghai 200025, Peoples R China
[4] Affiliated Hosp 1, Wenzhou Med Coll, Dept Endocrine & Metab Dis, Hangzhou 325000, Zhejiang, Peoples R China
[5] Shanghai Jiao Tong Univ, Sch Med, Div Endocrine & Metab Dis, E Inst Shanghai Univ,Ruijin Hosp, Shanghai 200025, Peoples R China
来源：
CLINICAL IMMUNOLOGY | 2008年 / 127卷 / 03期
关键词：
IL-16; Graves'disease; polymorphism;
D O I：
10.1016/j.clim.2008.01.017
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Interleukin (IL)-16 was one of the cytokines with the function of T helper cell recruitment, whose expression in the thyrocyte and orbital fibroblast of Graves' disease (GD) patients was increased. Recently association of IL-16 gene polymorphisms with autoimmune diseases had been reported. However, there was little known about the impact of IL-16 gene polymorphisms on GD. In this study, we performed a case-control association study of three tagSNPs (rs4778889-rs1131445-rs4778641) within the IL-16 gene on 258 patients with GD and 208 healthy subjects in the Chinese population. Our data showed that common IL-16 variants were associated with GD (P= 0.013-0.0186) and Graves' disease associated ophthalmopathy (GO) (P=0.0033-0.041). A novel protective haplotype containing the three tagSNPs (C-T-C) was observed in association with GO (P= 0.013). In conclusion, IL-16 gene was significantly associated with susceptibility to Graves' disease and Graves' disease associated ophthalmopathy in the Chinese population. (c) 2008 Elsevier Inc. All rights reserved.
引用
收藏
页码：298 / 302
页数：5
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