A novel rectal applicator for contact radiotherapy with HDR 192Ir sources

被引：6

作者：

Bellezzo, Murillo ^{[1
,2
]}

Fonseca, Gabriel P. ^{[1
]}

Verrijssen, An-Sofie ^{[1
]}

Voncken, Robert ^{[1
]}

Van den Bosch, Michiel R. ^{[1
]}

Yoriyaz, Helio ^{[2
]}

Reniers, Brigitte ^{[3
]}

Berbee, Maaike ^{[1
]}

Van Limbergen, Evert J. ^{[1
]}

Verhaegen, Frank ^{[1
]}

机构：

[1] Maastricht Univ, Dept Radiat Oncol MAASTRO, GROW Sch Oncol & Dev Biol, Med Ctr, NL-6201 BN Maastricht, Netherlands

[2] Inst Pesquisas Energet & Nucl IPEN CNEN SP, Ctr Engn Nucl, Sao Paulo, Brazil

[3] Hasselt Univ, Res Grp NuTeC, Ctr Environm Sci, Diepenbeek, Belgium

来源：

BRACHYTHERAPY | 2018年 / 17卷 / 06期

关键词：

Brachytherapy; Monte Carlo; Contact radiotherapy; Rectal applicator; QUALITY-OF-LIFE; X-RAY THERAPY; RADIATION-THERAPY; MONTE-CARLO; ORGAN PRESERVATION; TECHNICAL NOTE; BRACHYTHERAPY; CANCER; DOSIMETRY; ADENOCARCINOMA;

D O I：

10.1016/j.brachy.2018.07.012

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

PURPOSE: Dose escalation to rectal tumors leads to higher complete response rates and may thereby enable omission of surgery. Important advantages of endoluminal boosting techniques include the possibility to apply a more selective/localized boost than using external beam radiotherapy. A novel brachytherapy (BT) rectal applicator with lateral shielding was designed to be used with a rectoscope for eye-guided positioning to deliver a dose distribution similar to the one of contact x-ray radiotherapy devices, using commonly available high-dose-rate Ir-192 BT sources. METHODS AND MATERIALS: A cylindrical multichannel BT applicator with lateral shielding was designed by Monte Carlo modeling, validated experimentally with film dosimetry and compared with results found in the literature for the Papillon 50 (P50) contact x-ray radiotherapy device regarding rectoscope dimensions, radiation beam shape, dose fall-off, and treatment time. RESULTS: The multichannel applicator designed is able to deliver 30 Gy under 13 min with a 20350 U (5 Ci) source. The use of multiple channels and lateral shielding provide a uniform circular treatment surface with 22 mm in diameter. The resulting dose fall-off is slightly steeper (maximum difference of 5%) than the one generated by the P50 device with the 22 mm applicator. CONCLUSIONS: A novel multichannel rectal applicator for contact radiotherapy with high-dose-rate Ir-192 sources that can be integrated with commercially available treatment planning systems was designed to produce a dose distribution similar to the one obtained by the P50 device. (C) 2018 American Brachytherapy Society. Published by Elsevier Inc. All rights reserved.

引用

页码：1037 / 1044

页数：8

共 38 条

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