Hematoprotection by transfer of drug-resistance genes

被引：13

作者：

Flasshove, M ^{[1
]}

Moritz, T ^{[1
]}

Bardenheuer, W ^{[1
]}

Seeber, S ^{[1
]}

机构：

[1] Univ Essen Med Sch, W German Canc Ctr, Dept Internal Med Canc Res, DE-45122 Essen, Germany

来源：

ACTA HAEMATOLOGICA | 2003年 / 110卷 / 2-3期

关键词：

gene therapy; hematopoietic stem cells; drug resistance; retroviral vector;

D O I：

10.1159/000072458

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Myelosuppression represents a major side effect of cytotoxic anti-cancer agents. Infection due to granulocytopenia and the risk of bleeding due to thrombocytopenia compromise the potential of curative and palliative chemotherapy. Considering the many chemotherapeutic agents for which drug resistance genes have been described, and the recent improvements in vector and transduction technology, it seems conceivable that drug resistance gene transfer into a patient's autologous hematopoietic stem or progenitor cells will be able to reduce or abolish chemotherapy-induced myelosuppression. Copyright (C) 2003 S. Karger AG, Basel.

引用

页码：93 / 106

页数：14

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