Magnetic biochips: a new option for sensitive diagnostics

被引：124

作者：

Megens, M ^{[1
]}

Prins, M ^{[1
]}

机构：

[1] Philips Res Labs, NL-5656 AA Eindhoven, Netherlands

来源：

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS | 2005年 / 293卷 / 01期

关键词：

biosensor; medical diagnostics; giant magneto-resistance effect; magnetic actuation; integration; microdevices; assays; magnetic sensor; BARC; dynabeads; microchip;

D O I：

10.1016/j.jmmm.2005.02.046

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

We present an overview of miniaturized biosensor devices based on the sensitive detection of magnetic nanoparticles using the giant magneto-resistance effect. This detection principle has advantages over established methods, and the sensitivity is promising. In our opinion, the challenge is now in the integration-of sample pretreatment, in a cartridge, of nanoparticles with proper stabilization, magnetic properties, and surface functionalizations. (c) 2005 Published by Elsevier B.V.

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收藏

页码：702 / 708

页数：7

相关论文

共 28 条

[1]

Aytur T., 2002, SOL STAT SENS ACT MI, P126

[2] GIANT MAGNETORESISTANCE OF (001)FE/(001) CR MAGNETIC SUPERLATTICES [J].

BAIBICH, MN ;

BROTO, JM ;

FERT, A ;

VANDAU, FN ;

PETROFF, F ;

EITENNE, P ;

CREUZET, G ;

FRIEDERICH, A ;

CHAZELAS, J .

PHYSICAL REVIEW LETTERS, 1988, 61 (21) :2472-2475

[3] A biosensor based on magnetoresistance technology [J].

Baselt, DR ;

Lee, GU ;

Natesan, M ;

Metzger, SW ;

Sheehan, PE ;

Colton, RJ .

BIOSENSORS & BIOELECTRONICS, 1998, 13 (7-8) :731-739

[4] Detection of a single magnetic microbead using a miniaturized silicon Hall sensor [J].

Besse, PA ;

Boero, G ;

Demierre, M ;

Pott, V ;

Popovic, R .

APPLIED PHYSICS LETTERS, 2002, 80 (22) :4199-4201

[5] Detection of superparamagnetic markers with GMI-sensors [J].

Bethke, C ;

Yakabchuk, H ;

Tarasenko, V ;

Hammer, H ;

Kisker, E ;

Koppers, E ;

Christoph, S ;

Zirwes, R ;

Müller, J .

TECHNISCHES MESSEN, 2003, 70 (12) :574-576

[6] ENHANCED MAGNETORESISTANCE IN LAYERED MAGNETIC-STRUCTURES WITH ANTIFERROMAGNETIC INTERLAYER EXCHANGE [J].

BINASCH, G ;

GRUNBERG, P ;

SAURENBACH, F ;

ZINN, W .

PHYSICAL REVIEW B, 1989, 39 (07) :4828-4830

[7]

COEHOORN R, 2003, HDB MAGNETIC MAT

[8] The BARC biosensor applied to the detection of biological warfare agents [J].

Edelstein, RL ;

Tamanaha, CR ;

Sheehan, PE ;

Miller, MM ;

Baselt, DR ;

Whitman, LJ ;

Colton, RJ .

BIOSENSORS & BIOELECTRONICS, 2000, 14 (10-11) :805-813

[9] Biodetection using magnetically labeled biomolecules and arrays of spin valve sensors (invited) [J].

Ferreira, HA ;

Graham, DL ;

Freitas, PP ;

Cabral, JMS .

JOURNAL OF APPLIED PHYSICS, 2003, 93 (10) :7281-7286

[10] High sensitivity detection of molecular recognition using magnetically labelled biomolecules and magnetoresistive sensors [J].

Graham, DL ;

Ferreira, HA ;

Freitas, PP ;

Cabral, JMS .

BIOSENSORS & BIOELECTRONICS, 2003, 18 (04) :483-488