FOCUSED ULTRASOUND PLATFORM FOR INVESTIGATING THERAPEUTIC NEUROMODULATION ACROSS THE HUMAN HIPPOCAMPUS

被引：55

作者：

Brinker, Spencer T. ^{[1
]}

Preiswerk, Frank ^{[1
]}

White, Phillip J. ^{[1
,2
]}

Mariano, Timothy Y. ^{[3
,4
,5
]}

McDannold, Nathan J. ^{[1
]}

Bubrick, Ellen J. ^{[6
]}

机构：

[1] Harvard Med Sch, Brigham & Womens Hosp, Dept Radiol, Boston, MA 02115 USA

[2] Simmons Coll, Dept Phys, Boston, MA 02115 USA

[3] Providence Vet Affairs Med Ctr, Ctr Neurorestorat & Neurotechnol, Providence, RI USA

[4] Butler Hosp, Providence, RI 02906 USA

[5] Harvard Med Sch, Brigham & Womens Hosp, Dept Psychiat, Boston, MA 02115 USA

[6] Harvard Med Sch, Brigham & Womens Hosp, Dept Neurol, Boston, MA 02115 USA

来源：

ULTRASOUND IN MEDICINE AND BIOLOGY | 2020年 / 46卷 / 05期

基金：

美国国家卫生研究院;

关键词：

Low-intensity focused ultrasound; Therapeutic neuromodulation; Neuronavigation; Human hippocampus; Multitarget; STIMULATION; SYSTEM; ARRAY;

D O I：

10.1016/j.ultrasmedbio.2020.01.007

中图分类号：

O42 [声学];

学科分类号：

070206 ; 082403 ;

摘要：

Pulsed low-intensity focused ultrasound (PLIFUS) has shown promise in inducing neuromodulation in several animal and human studies. Therefore, it is of clinical interest to develop experimental platforms to test repetitive PLIFUS as a therapeutic modality in humans with neurologic disorders. In the study described here, our aim was to develop a laboratory-built experimental device platform intended to deliver repetitive PLIFUS across the hippocampus in seizure onset zones of patients with drug-resistant temporal lobe epilepsy. The system uses neuronavigation targeting over multiple therapeutic sessions. PLIFUS (548 kHz) was emitted across multiple hippocampal targets in a human subject with temporal lobe epilepsy using a mechanically steered piezoelectric transducer. Stimulation was delivered up to 2.25 W/cm(2) spatial peak temporal average intensity (free-field equivalent), with 36%-50% duty cycle, 500-ms sonications and 7-s inter-stimulation intervals lasting 140 s per target and repeated for multiple sessions. A firstin-human PLIFUS course of treatment was successfully delivered using the device platform with no adverse events. (C) 2020 World Federation for Ultrasound in Medicine & Biology. All rights reserved.

引用

页码：1270 / 1274

页数：5

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