Chronic amitriptyline treatment induces hippocampal NGFI-A, glucocorticoid receptor and mineralocorticoid receptor mRNA expression in rats

被引：25

作者：

Johansson, IM

Bjartmar, L

Marcusson, J

Ross, SB

Seckl, JR

Olsson, T ^{[1
]}

机构：

[1] Univ Umea Hosp, Dept Med, S-90185 Umea, Sweden

[2] Linkoping Univ, Dept Neurosci & Locomot, Div Geriatr, Linkoping, Sweden

[3] Western Gen Hosp, Dept Med, Edinburgh EH4 2XU, Midlothian, Scotland

来源：

MOLECULAR BRAIN RESEARCH | 1998年 / 62卷 / 01期

基金：

英国惠康基金;

关键词：

NGFI-A; glucocorticoid receptor; antidepressant; hippocampus; transcription factor;

D O I：

10.1016/S0169-328X(98)00243-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Adult male rats were treated with the antidepressant drug amitriptyline for 21 days and the expression of specific transcription factors was examined. NGFI-A mRNA expression was increased in the hippocampus and in the cerebral cortex. MR mRNA was increased in the hippocampus while GR mRNA was increased in selective hippocampal regions, There was no change in the NGFI-B mRNA expression. Thus, NCFI-A may be a mediator of plasticity-related phenomena induced by antidepressant drugs. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：92 / 95

页数：4

共 18 条

[1] LONG-TERM ANTIDEPRESSANT ADMINISTRATION ALTERS CORTICOTROPIN-RELEASING HORMONE, TYROSINE-HYDROXYLASE, AND MINERALOCORTICOID RECEPTOR GENE-EXPRESSION IN RAT-BRAIN - THERAPEUTIC IMPLICATIONS [J].