Natural Products as Leads for Tuberculosis Drug Development

被引：1

作者：

Salomon, Christine E. ^{[1
]}

Schmidt, Lori E. ^{[1
]}

机构：

[1] Univ Minnesota, Ctr Drug Design, Minneapolis, MN 55455 USA

来源：

CURRENT TOPICS IN MEDICINAL CHEMISTRY | 2012年 / 12卷 / 07期

关键词：

Natural products; tuberculosis; drug development; mycobacterium tuberculosis; drug resistant tuberculosis; structure activity relationship; ENDIANDRIC ACID CASCADE; RESISTANT MYCOBACTERIUM-TUBERCULOSIS; STEREOCONTROLLED TOTAL-SYNTHESIS; PSEUDOMONAS SP F92S91; TUMOR-CELL LINES; ANTIMYCOBACTERIAL ACTIVITY; ANTITUBERCULAR CONSTITUENTS; GROWTH-INHIBITORS; ORGANIC-SYNTHESIS; SECONDARY METABOLITES;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

New therapeutics are urgently needed to combat the immense disease burden of tuberculosis and related mycobacterial diseases worldwide. Natural products continue to provide leads for the development of novel drugs to treat the rapidly growing numbers of patients with multi- and extensively-drug resistant tuberculosis. This review presents natural products and synthesized analogues with anti-mycobacterial activity published between 2006 through 2009. Structure activity relationships, synthetic analogues and newly reported activities of known compounds reported during this period are also included.

引用

页码：735 / 765

页数：31

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