A ratiometric fluorescent probe based on a Bodipy-Coumarin conjugate for sensing of nitroxyl in living cells

被引：46
作者：
Zheng, Kaibo [1 ]
Chen, Hui [1 ]
Fang, Shirong [2 ]
Wang, Ying [1 ]
机构：
[1] China Three Gorges Univ, Coll Mat & Chem Engn, Key Lab Inorgan Nonmet Crystalline & Energy Conve, Yichang 443002, Peoples R China
[2] Univ Hosp Hubei Univ Nationalities, Dept Resp, Enshi 445000, Peoples R China
来源：
SENSORS AND ACTUATORS B-CHEMICAL | 2016年 / 233卷
关键词：
Ratiometric fluorescent probe; Bodipy-Coumarin; Nitroxyl; Imaging; IN-VIVO; HYDROGEN-SULFIDE; REDUCTANT-RESISTANT; SELECTIVE DETECTION; DESIGN STRATEGIES; AQUEOUS-SOLUTION; FAST-RESPONSE; HNO; PH; SERUM;
D O I：
10.1016/j.snb.2016.04.053
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A ratiometric fluorescent HNO probe Bod-Cou-HNO based on a Bodipy-Coumarin platform, and a sensitive HNO recognition site, triarylphosphine was constructed. The probe Bod-Cou-HNO exhibits desirable properties such as high sensitivity, high selectivity, remarkable emission shift (up to 129 nm) and low cytotoxicity. Significantly, we have demonstrated that the probe Bod-Cou-HNO is suitable for fluorescence ratiometric imaging of HNO in living cells. The further application of the ratiometric fluorescence probe Bod-Cou-HNO for the investigation of biological functions of HNO in biosystems is under progress. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：193 / 198
页数：6
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