Distinct Patterns of Antiamyloid-β Antibodies in Typical and Atypical Alzheimer Disease

被引：22

作者：

Dorothee, Guillaume ^{[2
]}

Bottlaender, Michel ^{[3
,4
]}

Moukari, Edmond ^{[2
]}

de Souza, Leonardo C. ^{[5
,6
]}

Maroy, Renaud ^{[3
]}

Corlier, Fabian ^{[5
,6
]}

Colliot, Olivier ^{[5
,7
]}

Chupin, Marie ^{[5
,7
]}

Lamari, Foudil ^{[8
]}

Lehericy, Stephane ^{[5
,7
,9
]}

Dubois, Bruno ^{[5
,6
]}

Sarazin, Marie ^{[1
,5
,6
]}

Aucouturier, Pierre ^{[2
]}

机构：

[1] Hop La Pitie Salpetriere, AP HP, Dept Neurol, Res & Resource Memory Ctr, F-75013 Paris, France

[2] Hop St Antoine, INSERM, UMRS938, F-75012 Paris, France

[3] CEA, Serv Hosp Frederic Joliot, DSV, I2BM, F-91406 Orsay, France

[4] CEA, DSV, I2BM, F-91191 Gif Sur Yvette, France

[5] Univ Paris 06, CRICM, Pitie Salpetriere Hosp, Paris, France

[6] Hop La Pitie Salpetriere, AP HP, Ctr Reference Demences Rares, Ctr Reference Malad Alzheimer Jeune, F-75013 Paris, France

[7] Hop La Pitie Salpetriere, CNRS, UMR 7225, F-75013 Paris, France

[8] Hop La Pitie Salpetriere, AP HP, Dept Metab Biochem, F-75013 Paris, France

[9] Hop La Pitie Salpetriere, Ctr Neuroimaging Res CENIR, Dept Neuroradiol, F-75013 Paris, France

来源：

ARCHIVES OF NEUROLOGY | 2012年 / 69卷 / 09期

关键词：

POSTERIOR CORTICAL ATROPHY; AMYLOID-BETA; COGNITIVE IMPAIRMENT; AUTOANTIBODIES; BURDEN;

D O I：

10.1001/archneurol.2012.604

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective: To compare serum antiamyloid-beta (A beta) antibodies in typical and atypical Alzheimer disease (AD). Design: Preliminary observations. Subjects: Thirteen patients with AD, 8 patients with posterior cortical atrophy with evidence of AD (PCA-AD) pathophysiological process by both cerebrospinal fluid (CSF) biomarkers and amyloid imaging, and 12 age-matched control individuals. Interventions: The class and subclass levels of serum anti-A beta antibodies were measured using an oligomer-based enzyme-linked immunosorbent assay. This method allowed measuring both free antibodies and, after acidic treatment, the total fraction that includes all antibodies complexed with circulating A beta(40/42) and any cross-reacting antigen. Results: Anti-A beta IgG were restricted to the IgG1 and IgG3 subclasses. Their total levels were strikingly lower and more homogeneous in patients with PCA compared with both typicalADand controls, while biomarkers of amyloid deposition (CSFA beta(42) and positron emission tomography amyloid imaging) were similar in patients with AD and patients with PCA. Conclusions: Serum anti-A beta IgG1 and IgG3 antibodies differ between distinct forms of AD. Its significance is discussed for possible implications as immune effectors in the specific pathophysiology of AD variants. Arch Neurol. 2012; 69(9): 1181-1185. Published online June 18, 2012. doi: 10.1001/archneurol.2012.604

引用

页码：1181 / 1185

页数：5

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