Effects of Compound Danshen tablets on spatial cognition and expression of brain β-amyloid precursor protein in a rat model of alzheimer's disease

被引：40

作者：

Qin Ren-an ^{[1
]}

Yao Xiao-xuan ^{[1
]}

Huang Zhu-ying ^{[1
]}

机构：

[1] Guangzhou Baiyunshan Hutchison Whampoa Chinese Me, Modern Chinese Med Inst, Guangzhou 510515, Guangdong, Peoples R China

来源：

JOURNAL OF TRADITIONAL CHINESE MEDICINE | 2012年 / 32卷 / 01期

关键词：

Compound Danshen Tablets (CDST); Alzheimer's disease; B-amyloid precursor protein;

D O I：

10.1016/S0254-6272(12)60033-8

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

OBJECTIVE: To observe the effects of Compound Danshen Tablets (CDST) on spatial cognition and expression of brain b-amyloid precursor protein (beta-APP) in a rat model of Alzheimer's disease. METHODS: The rat model of Alzheimer's disease (AD) was established using D-galactose to cause subacute aging combined with Meynert nucleus damage. Rat behavior was monitored using the Morris water maze, and the expression of beta-APP in rat brain tissue was detected via immunohistochemistry. RESULTS: CDST significantly improved spatial cognition and decreased beta-APP expression in the cortex and hippocampus (P<0.05, P<0.01). CONCLUSIONS: CDST can significantly improve spatial cognition in a rat model of AD. This observation is possibly related to reduction in beta-APP expression in the rat brain. (C) 2012 JTCM. All rights reserved.

引用

页码：63 / 66

页数：4

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