Lysine-specific demethylase 1 (LSD1) and histone deacetylase 1 (HDAC1) synergistically repress proinflammatory cytokines and classical complement pathway components

被引：26
|
作者：
Janzer, Andreas [1 ]
Lim, Soyoung [2 ]
Fronhoffs, Florian [1 ]
Niazy, Naima [1 ]
Buettner, Reinhard [2 ]
Kirfel, Jutta [1 ]
机构：
[1] Univ Bonn, Inst Pathol, D-53127 Bonn, Germany
[2] Univ Cologne, Inst Pathol, D-50924 Cologne, Germany
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2012年 / 421卷 / 04期
关键词：
Histone demethylases; LSD1; HDAC; Transcription; Inflammation; NECROSIS-FACTOR-ALPHA; CHROMATIN MODIFICATIONS; EPIGENETIC REGULATION; GENE-EXPRESSION; METHYLATION; INFLAMMATION; H3; CANCER; CELLS; PHOSPHORYLATION;
D O I：
10.1016/j.bbrc.2012.04.057
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Histone modifying enzymes confer epigenetic marks, directing the changes in gene expression required for diverse cellular processes. Lysine-specific demethylase 1 (LSD1) functions as a transcriptional coregulator by demethylating histone H3 on lysine 4 and lysine 9. Analyzing transcriptomes on microarrays, we identified genes which represent inflammatory-related targets of LSD1. We demonstrate a repressive role of LSD1 in proinflammatory cytokine expression such as IL1 alpha, IL1 beta, IL6 and IL8 and classical complement components. Consistently, LSD1 occupies and regulates the promoter of these genes. In addition, we demonstrate that HDAC1 and LSD1 synergistically regulate these inflammatory-related genes. Our data reveal a novel role for LSD1 in suppressing immune responses. Crown Copyright (C) 2012 Published by Elsevier Inc. All rights reserved.
引用
收藏
页码：665 / 670
页数：6
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