Lycojaponicumins A-C, Three Alkaloids with an Unprecedented Skeleton from Lycopodium japonicum

被引：69

作者：

Wang, Xiao-Jing ^{[1
,2
]}

Zhang, Gui-Jie ^{[1
,2
]}

Zhuang, Peng-Yu ^{[1
,2
]}

Zhang, Yan ^{[1
,2
]}

Yu, Shi-Shan ^{[1
,2
]}

Bao, Xiu-Qi ^{[1
,2
]}

Zhang, Dan ^{[1
,2
]}

Yuan, Yu-He ^{[1
,2
]}

Chen, Nai-Hong ^{[1
,2
]}

Ma, Shuang-gang ^{[1
,2
]}

Qu, Jing ^{[1
,2
]}

Li, Yong ^{[1
,2
]}

机构：

[1] Chinese Acad Med Sci, State Key Lab Bioact Subst & Funct Nat Med, Inst Mat Med, Beijing 100050, Peoples R China

[2] Peking Union Med Coll, Beijing 100050, Peoples R China

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 10期

关键词：

FAWCETTIMINE-RELATED ALKALOIDS; (+)-FAWCETTIDINE; MACROPHAGES; COMPOUND; THUNB;

D O I：

10.1021/ol3009478

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Lycojaponicumins A-C (1-3), three trace alkaloids isolated from Lycopodium japonicum, represent a unique heterocyclic skeleton formed by the new linkage C4-C9. Notably, lycojaponicumins A and B (1 and 2) are the first examples of natural products possessing a 5/5/5/5/6 pentacyclic ring system with a 1-aza-7-oxabicyclo[2.2.1]heptane moiety. These structures were elucidated by spectroscopic methods and X-ray diffraction analysis. A plausible biogenetic pathway was proposed.

引用

页码：2614 / 2617

页数：4

共 37 条

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[Anonymous], 2010, PHARMACOPOEIA PEOP 1, P165

[2]

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