Synthesis and pharmacological evaluation of a new targeted drug carrier system:: β-Cyclodextrin coupled to oxytocin

被引：21

作者：

Bertolla, Carine ^{[1
]}

Rolin, Stephanie ^{[1
]}

Evrard, Brigitte ^{[2
]}

Pochet, Lionel ^{[1
]}

Masereel, Bernard ^{[1
]}

机构：

[1] Univ Namur, Drug Design & Discovery Ctr, FUNDP, B-5000 Namur, Belgium

[2] Univ Liege, Dept Pharm, Pharmaceut Technol Lab, B-4000 Liege, Belgium

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 06期

关键词：

D O I：

10.1016/j.bmcl.2008.02.017

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

beta-Cyclodextrin (beta-CD) was monofunctionalized into its carboxylic derivative and then conjugated to the N-side of oxytocin (OT), a nonapeptide involved in human behavior and myometrium contraction. On isolated rat myometrium, this conjugate (beta-CD-OT) partly preserves the contracting activity of OT (EC50 = 0.40 mu M vs 1.7 nM). Moreover, the contraction induced frequency is also lowered by beta-CD-OT. This novel hydrophilic targeted carrier could form a host-guest complex with prostaglandins and their derivatives used as labor inducers or with anticancer drugs used in cervix and endometrial cancer. This strategy can improve the solubility, the stability, and/or the biological activity of these drugs as well as reducing their side-effects. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：1855 / 1858

页数：4

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