A carboxylate-assisted amination/unactivated C(sp2)-H arylation reaction via a palladium/norbornene cooperative catalysis

被引：24

作者：

An, Yang ^{[1
]}

Zhang, Bo-Sheng ^{[1
]}

Zhang, Zhe ^{[1
]}

Liu, Ce ^{[1
]}

Gou, Xue-Ya ^{[1
]}

Ding, Ya-Nan ^{[1
]}

Liang, Yong-Min ^{[1
]}

机构：

[1] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2020年 / 56卷 / 44期

基金：

中国国家自然科学基金;

关键词：

INTRAMOLECULAR ALKANE ARYLATION; C-H FUNCTIONALIZATION; PHENANTHRIDINE DERIVATIVES; OXIDATIVE CYCLIZATION; ARYL IODIDES; METAL-FREE; BOND; CONSTITUENTS; ALKALOIDS; AMINATION;

D O I：

10.1039/c9cc09265j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This report describes a carboxylate-assisted palladium-catalysed Catellani reaction, which is compatible with ortho-amination and unactivated C(sp(2))-H arylation. This method was used to synthesize a series of 1-amino substituted dihydrophenanthridines, phenanthridines and 6H-benzo[c]chromenes. Based on kinetic isotope experiments, the kinetic curve proves that pivalic acid accelerates the reaction rate of unactivated C(sp(2))-H activation, and thus this rate can keep up with the five membered aryl-norbornene-palladacycle (ANP) intermediate.

引用

页码：5933 / 5936

页数：4

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