Genetic Polymorphism in IL28B Is Associated With Spontaneous Clearance of Hepatitis C Virus Genotype 4 Infection in an Egyptian Cohort

被引：41

作者：

Kurbanov, Fuat ^{[1
]}

Abdel-Hamid, Mohamed ^{[2
]}

Latanich, Rachel ^{[1
]}

Astemborski, Jacquie ^{[1
]}

Mohamed, Mostafa ^{[3
]}

Mikhail, Nabiel M. H. ^{[4
]}

El-Daly, Mai ^{[5
]}

El-Kafrawy, Sherif ^{[5
]}

Thomas, David L. ^{[1
]}

Thio, Chloe L. ^{[1
]}

机构：

[1] Johns Hopkins Univ, Dept Med, Baltimore, MD USA

[2] Menia Univ, Fac Med, Dept Microbiol & Immunol, Cairo, Egypt

[3] Ain Shams Univ, Dept Publ Hlth, Cairo, Egypt

[4] Assiut Univ, S Egypt Canc Inst, Dept Biostat & Canc Epidemiol, Asyut, Egypt

[5] Natl Liver Inst, Dept Clin Pathol, Mol Biol Unit, Menophyia, Egypt

来源：

JOURNAL OF INFECTIOUS DISEASES | 2011年 / 204卷 / 09期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1093/infdis/jir536

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Single-nucleotide polymorphisms (SNPs) around IL28B are associated with spontaneous hepatitis C virus (HCV) clearance of genotypes 1 and 3 in white and African-American populations. This study investigated whether the IL28B SNP (rs12979860) is associated with spontaneous clearance of HCV, principally genotype 4, in 162 Egyptians (80 with clearance). The protective C allele was more common in those with spontaneous clearance (76.3% vs 57.9%; P = 0.0006). Individuals with clearance were 3.4 (95% confidence interval, 1.8-6.5) times more likely to have C/C genotype. Thus, IL28B plays a role in spontaneous clearance of HCV genotype 4 in North Africa.

引用

页码：1391 / 1394

页数：4

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