In Vivo Characterizations of the Immune Properties of Sericin: An Ancient Material with Emerging Value in Biomedical Applications

被引：75

作者：

Jiao, Zhanying ^{[1
]}

Song, Yu ^{[1
]}

Jin, Yang ^{[2
]}

Zhang, Cheng ^{[1
]}

Peng, Dong ^{[1
]}

Chen, Zhenzhen ^{[1
]}

Chang, Panpan ^{[3
]}

Kundu, Subhas C. ^{[4
]}

Wang, Guobin ^{[5
]}

Wang, Zheng ^{[1
,5
]}

Wang, Lin ^{[1
,6
]}

机构：

[1] Huazhong Univ Sci & Technol, Res Ctr Tissue Engn & Regenerat Med, Union Hosp, Tongji Med Coll, Wuhan 430022, Hubei, Peoples R China

[2] Huazhong Univ Sci & Technol, Dept Respirat, Union Hosp, Tongji Med Coll, Wuhan 430022, Hubei, Peoples R China

[3] Huazhong Univ Sci & Technol, Med Res Ctr, Union Hosp, Tongji Med Coll, Wuhan 430022, Hubei, Peoples R China

[4] Univ Minho, Res Grp 3Bs, Headquarters European Inst Excellence Tissue Engn, AvePk, P-4805017 Barco, Guimaraes, Portugal

[5] Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Gastrointestinal Surg, Wuhan 430022, Hubei, Peoples R China

[6] Huazhong Univ Sci & Technol, Dept Clin Lab, Union Hosp, Tongji Med Coll, Wuhan 430022, Hubei, Peoples R China

来源：

MACROMOLECULAR BIOSCIENCE | 2017年 / 17卷 / 12期

基金：

中国国家自然科学基金;

关键词：

allergenicity; immunogenicity; inflammatory; sericin; silk; CHITOSAN-BASED HYDROGELS; SILK SERICIN; ASTHMA; IMMUNOGENICITY; MODELS; ALLERGENICITY; BIOMATERIALS; DELIVERY; COLLAGEN; SCAFFOLD;

D O I：

10.1002/mabi.201700229

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The biosafety of sericin remains controversial. The misunderstanding regarding sericin causing adverse biological responses have been clarified by extensively reviewing relevant literatures and experimentally demonstrating that sericin exhibits mild inflammatory responses, negligible allergenicity, and low immunogenicity in vivo. This study supports that sericin is biosafe as a natural biomaterial.

引用

页数：6

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