Studying non-covalent drug-DNA interactions

被引：333

作者：

Rehman, Sayeed Ur ^{[1
]}

Sarwar, Tarique ^{[1
]}

Husain, Mohammed Amir ^{[1
]}

Ishqi, Hassan Mubarak ^{[1
]}

Tabish, Mohammad ^{[1
]}

机构：

[1] Aligarh Muslim Univ, Fac Life Sci, Dept Biochem, Aligarh 202002, Uttar Pradesh, India

来源：

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 2015年 / 576卷

关键词：

Drug-DNA binding; Intercalation; Groove binding; Electrostatic interactions; CALF THYMUS DNA; CRYSTAL-STRUCTURE; IN-VITRO; MOLECULAR DOCKING; DEOXYRIBONUCLEIC-ACID; CAUSES PHOTOCLEAVAGE; CIRCULAR-DICHROISM; FLUORESCENT-PROBE; METAL-COMPLEXES; BINDING;

D O I：

10.1016/j.abb.2015.03.024

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Drug-DNA interactions have been extensively studied in the recent past. Various techniques have been employed to decipher these interactions. DNA is a major target for a wide range of drugs that may specifically or non-specifically interact with DNA and affect its functions. Interaction between small molecules and DNA are of two types, covalent interactions and non-covalent interactions. Three major modes of non-covalent interactions are electrostatic interactions, groove binding and intercalative binding. This review primarily focuses on discussing various techniques used to study non-covalent interactions that occur between drugs and DNA. Additionally, we report several techniques that may be employed to analyse the binding mode of a drug with DNA. These techniques provide data that are reliable and simple to interpret. (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：49 / 60

页数：12

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