Genomic Characterization of De Novo Metastatic Breast Cancer

被引：1

作者：

Mullangi, Samyukta ^{[1
,3
]}

Vasan, Neil ^{[2
,3
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USA

[2] Columbia Univ, Dept Med, Div Hematol Oncol, Irving Med Ctr, New York, NY 10032 USA

[3] Columbia Univ, Herbert Irving Comprehens Canc Ctr, Irving Med Ctr, New York, NY 10032 USA

来源：

CLINICAL BREAST CANCER | 2022年 / 22卷 / 02期

关键词：

STAGE IV; SURVIVAL; LANDSCAPE; LETROZOLE;

D O I：

10.1016/j.clbc.2021.11.005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

De novo metastatic breast cancer (dnMBC) represents a minority of MBC cases, and as such, its genomics are poorly understood. Characterizing the genomics of dnMBC represents an opportunity to delineate metastatic drivers in the absence of treatment selection. In this review, we first summarize the literature of the genomics of MBC which showed that MBCs have greater mutational burden than early stage, treatment naive breast cancers. We then turn to recent studies that have sought to focus on dnMBC. We propose that understanding genomic differences between dnMBC and relapsed MBC can inform treatment choices. Finally, we discuss translational strategies to better dissect the genomics of dnMBC. (C) 2021 Elsevier Inc. All rights reserved.

引用

页码：98 / 102

页数：5

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