Association between the catechol O-methyltransferase Val108/158Met polymorphism and alexithymia

被引:37
作者
Ham, BJ
Lee, MS
Lee, YM
Kim, MK
Choi, MJ
Oh, KS
Jung, HY
Lyoo, IK
Choi, IG
机构
[1] Hallym Univ, Med Ctr, Hangang Sacred Heart Hosp, Dept Neuropsychiat, Chunchon, South Korea
[2] Korea Univ, Coll Med, Dept Psychiat, Seoul, South Korea
[3] Korea Univ, Coll Med, Dept Med Educ, Seoul, South Korea
[4] Korea Univ, Coll Med, Dept Biochem, Seoul, South Korea
[5] Sungkyunkwan Univ, Sch Med, Kangbuk Samsung Hosp, Dept Psychiat, Seoul, South Korea
[6] Soonchunhyang Univ, Coll Med, Dept Psychiat, Seoul, South Korea
[7] Seoul Natl Univ, Coll Med, Dept Psychiat, Seoul, South Korea
关键词
alexithymia; catechol O-methyltransferase; 5-HTTLPR polymorphism;
D O I
10.1159/000087846
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
It has been suggested that the characteristics of alexithymia result from deficits in frontal lobe functioning, and the prefrontal cortex is particularly dependent on the catechol O-methyltransferase (COMT) pathway. We investigated the relationship between COMT Val108/158Met, serotonin transporter coding sequence (5-HT transporter gene-linked polymorphic region; 5-HTTLPR) polymorphisms, and alexithymia. The study sample comprised 109 students at the Korea University. All participants were tested using the 20-item Toronto Alexithymia Scale (TAS-20). They were genotyped for COMT Val108/158Met and 5-HTTLPR polymorphisms. Genotyping was analyzed using polymerase chain reaction. Subjects with Val/Val genotype had significantly higher TAS-20 scores than those with Met/Met or Met/Val genotypes. However, there was no significant relationship between the 5-HTTLPR genotype and TAS-20 scores. This indicates a possible association between the COMT Val108/158Met gene polymorphism and alexithymia. Copyright (C) 2005 S. Karger AG, Basel.
引用
收藏
页码:151 / 154
页数:4
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