The dual role of alpha7 nicotinic acetylcholine receptor in inflammation-associated gastrointestinal cancers

被引：32

作者：

Hajiasgharzadeh, Khalil ^{[1
]}

Somi, Mohammad Hossein ^{[2
]}

Sadigh-Eteghad, Saeed ^{[3
]}

Mokhtarzadeh, Ahad ^{[1
]}

Shanehbandi, Dariush ^{[1
]}

Mansoori, Behzad ^{[1
]}

Mohammadi, Ali ^{[4
]}

Doustvandi, Mohammad Amin ^{[1
]}

Baradaran, Behzad ^{[1
]}

机构：

[1] Tabriz Univ Med Sci, Immunol Res Ctr, Tabriz, Iran

[2] Tabriz Univ Med Sci, Liver & Gastrointestinal Dis Res Ctr, Tabriz, Iran

[3] Tabriz Univ Med Sci, Neurosci Res Ctr, Tabriz, Iran

[4] Univ Southern Denmark, Inst Mol Med, Dept Canc & Inflammat Res, Odense, Denmark

来源：

HELIYON | 2020年 / 6卷 / 03期

关键词：

Clinical research; Gastrointestinal system; Immunology; Oncology; Pharmacology; Physiology; Alpha7 nicotinic acetylcholine receptor; Cholinergic anti-inflammatory pathway; Gastrointestinal cancers; Inflammation; Cancer regulation; NF-KAPPA-B; HEART-RATE-VARIABILITY; TUMOR-NECROSIS-FACTOR; GASTRIC-CANCER; VAGUS NERVE; PANCREATIC-CANCER; MOLECULAR-MECHANISMS; NONALCOHOLIC STEATOHEPATITIS; CELL-PROLIFERATION; SIGNALING PATHWAY;

D O I：

10.1016/j.heliyon.2020.e03611

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Alpha7 nicotinic acetylcholine receptor (alpha 7nAChR) is one of the main subtypes of nAChRs that modulates various cancer-related properties including proliferative, anti-apoptotic, pro-angiogenic and pro-metastatic activities in most of the cancers. It also plays a crucial role in inflammation control through the cholinergic anti-inflammatory pathway in numerous pathophysiological contexts. Such diverse physiological and pathological functions that initiate from this receptor may have significant impacts in determining the outcome of different cancers. Various tissues of gastrointestinal (GI) cancers such as gastric, colorectal, pancreatic and liver cancers have shown the upregulated expression of alpha 7nAChR as compared to normal adjacent tissues. According to the well-established connection between inflammation and tumorigenesis in the digestive system, there are mounting studies demonstrated either stimulatory or inhibitory effects of alpha 7nAChR signaling in the development of GI cancers. To date, the precise underlying mechanisms related to this receptor in patients with GI cancers have not been fully elucidated. Regarding the paradoxical modulatory effects of this receptor in carcinogenesis, in this review, we aim to summarize the accumulated evidence about the involvement of alpha 7nAChR in inflammation-associated GI cancers. It seems that the complex influences of alpha 7nAChR may be a promising target in designing novel strategies

引用

页数：8

共 108 条

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