Quantitative analysis demonstrates most transcription factors require only simple models of specificity

被引：135

作者：

Zhao, Yue ^{[1
]}

Stormo, Gary D. ^{[1
]}

机构：

[1] Washington Univ, Sch Med, St Louis, MO 63130 USA

来源：

NATURE BIOTECHNOLOGY | 2011年 / 29卷 / 06期

关键词：

PROTEIN-DNA INTERACTIONS; MICROARRAYS;

D O I：

10.1038/nbt.1893

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

引用

页码：480 / 483

页数：2

共 11 条

[1] High Resolution Models of Transcription Factor-DNA Affinities Improve In Vitro and In Vivo Binding Predictions [J].

Agius, Phaedra ;

Arvey, Aaron ;

Chang, William ;

Noble, William Stafford ;

Leslie, Christina .

PLOS COMPUTATIONAL BIOLOGY, 2010, 6 (09)

[2] Diversity and Complexity in DNA Recognition by Transcription Factors [J].

Badis, Gwenael ;

Berger, Michael F. ;

Philippakis, Anthony A. ;

Talukder, Shaheynoor ;

Gehrke, Andrew R. ;

Jaeger, Savina A. ;

Chan, Esther T. ;

Metzler, Genita ;

Vedenko, Anastasia ;

Chen, Xiaoyu ;

Kuznetsov, Hanna ;

Wang, Chi-Fong ;

Coburn, David ;

Newburger, Daniel E. ;

Morris, Quaid ;

Hughes, Timothy R. ;

Bulyk, Martha L. .

SCIENCE, 2009, 324 (5935) :1720-1723

[3] Additivity in protein-DNA interactions: how good an approximation is it? [J].

Benos, PV ;

Bulyk, ML ;

Stormo, GD .

NUCLEIC ACIDS RESEARCH, 2002, 30 (20) :4442-4451

[4] Compact, universal DNA microarrays to comprehensively determine transcription-factor binding site specificities [J].

Berger, Michael F. ;

Philippakis, Anthony A. ;

Qureshi, Aaron M. ;

He, Fangxue S. ;

Estep, Preston W., III ;

Bulyk, Martha L. .

NATURE BIOTECHNOLOGY, 2006, 24 (11) :1429-1435

[5] Exploring the DNA-binding specificities of zinc fingers with DNA microarrays [J].

Bulyk, ML ;

Huang, XH ;

Choo, Y ;

Church, GM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (13) :7158-7163

[6] Protein-DNA interactions: Amino acid conservation and the effects of mutations on binding specificity [J].

Luscombe, NM ;

Thornton, JM .

JOURNAL OF MOLECULAR BIOLOGY, 2002, 320 (05) :991-1009

[7] UniPROBE: an online database of protein binding microarray data on protein-DNA interactions [J].

Newburger, Daniel E. ;

Bulyk, Martha L. .

NUCLEIC ACIDS RESEARCH, 2009, 37 :D77-D82

[8] Determining the specificity of protein-DNA interactions [J].

Stormo, Gary D. ;

Zhao, Yue .

NATURE REVIEWS GENETICS, 2010, 11 (11) :751-760

[9] DNA binding sites: representation and discovery [J].

Stormo, GD .

BIOINFORMATICS, 2000, 16 (01) :16-23

[10]

STORMO GD, 2011, GENETICS 0204, DOI DOI 10.1534/GENETICS.110.126052

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