Antidepressant Active Ingredients From Chinese Traditional Herb Panax Notoginseng: A Pharmacological Mechanism Review

被引：11

作者：

Li, Yanwei ^{[1
]}

Guo, Qingwan ^{[2
]}

Huang, Junqing ^{[1
]}

Wang, Ziying ^{[2
]}

机构：

[1] Jinan Univ, Guangzhou Key Lab Formula Pattern Res Ctr, Sch Tradit Chinese Med, Guangzhou, Peoples R China

[2] Jinan Univ, Sch Tradit Chinese Med, Interdisciplinary Inst Personalized Med, Guangzhou, Peoples R China

来源：

FRONTIERS IN PHARMACOLOGY | 2022年 / 13卷

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

depression; chinese herbal medicine; Panax notoginseng; active ingredients; antidepressant; DEPRESSION-LIKE BEHAVIORS; WITNESSING TRAUMATIC EVENTS; GINSENOSIDE RG1; MONONEUROPATHY INVOLVEMENT; MAJOR DEPRESSION; ANIMAL-MODELS; GAP-JUNCTIONS; MICE; BDNF; EXPRESSION;

D O I：

10.3389/fphar.2022.922337

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Depression is one of the most common mental illnesses in the world and is highly disabling, lethal, and seriously endangers social stability. The side effects of clinical drugs used to treat depression are obvious, and the onset time is longer. Therefore, there is a great demand for antidepressant drugs with better curative effects, fewer side effects, and shorter onset time. Panax notoginseng, a Chinese herbal medication, has been used to treat depression for thousands of years and shown to have a therapeutic effect on depression. This review surveyed PubMed's most recent 20 years of research on Panax notoginseng's use for treating depression. We mainly highlight animal model research and outlined the pathways influenced by medicines. We provide a narrative review of recent empirical evidence of the anti-depressive effects of Panax Notoginseng and novel ideas for developing innovative clinical antidepressants with fewer side effects.

引用

页数：17

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