Cysteine-Activated Hydrogen Sulfide (H2S) Donors

被引：206

作者：

Zhao, Yu ^{[1
]}

Wang, Hua ^{[1
]}

Xian, Ming ^{[1
]}

机构：

[1] Washington State Univ, Dept Chem, Pullman, WA 99164 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2011年 / 133卷 / 01期

基金：

美国国家科学基金会;

关键词：

S-NITROSOTHIOLS; REDUCTIVE LIGATION; PLASMA; HOMOCYSTEINE; INSIGHTS;

D O I：

10.1021/ja1085723

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

H2S, the newly discovered gasotransmitter, plays important roles in biological systems. However, the research on H2S has been hindered by the lack of controllable H2S donors that could mimic the slow and continuous H2S generation process in vivo. Herein we report a series of cysteine-activated H2S donors. Structural modifications of these molecules can regulate the rates of H2S generation. These compounds can be useful tools in H2S research.

引用

页码：15 / 17

页数：3

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