The dynamics of chromosome organization and gene regulation

被引：270
作者：
Spector, DL [1 ]
机构：
[1] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA
来源：
ANNUAL REVIEW OF BIOCHEMISTRY | 2003年 / 72卷
关键词：
gene expression; transcription; nuclear structure; nuclear dynamics;
D O I：
10.1146/annurev.biochem.72.121801.161724
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
With the sequence of the human genome now complete, studies must focus on how the genome is functionally organized within the confines of the cell nucleus and the dynamic interplay between the genome and its regulatory factors to effectively control gene expression and silencing. In this review I describe our current state of knowledge with regard to the organization of chromosomes within the nucleus and the positioning of active versus inactive genes. In addition, I discuss studies on the dynamics of chromosomes and specific genetic loci within living cells and its relationship to gene activity and the cell cycle. Furthermore, our current understanding of the distribution and dynamics of RNA polymerase 11 transcription factors is discussed in relation to chromosomal loci and other nuclear domains.
引用
收藏
页码：573 / 608
页数：36
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