Tetrahydrobiopterin: pleiotropic roles in cardiovascular pathophysiology

被引：44

作者：

Cunnington, Colin ^{[1
]}

Channon, Keith M. ^{[1
]}

机构：

[1] Univ Oxford, Dept Cardiovasc Med, John Radcliffe Hosp, Oxford OX3 9DU, England

来源：

HEART | 2010年 / 96卷 / 23期

关键词：

NITRIC-OXIDE SYNTHASE; ENDOTHELIUM-DEPENDENT VASODILATION; CORONARY-ARTERY-DISEASE; VASCULAR SUPEROXIDE-PRODUCTION; ISCHEMIA-REPERFUSION INJURY; PULMONARY-HYPERTENSION; CARDIAC-HYPERTROPHY; GTP-CYCLOHYDROLASE; DIABETES-MELLITUS; CONSCIOUS RABBITS;

D O I：

10.1136/hrt.2009.180430

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Tetrahydrobiopterin (BH4) functions as a cofactor in several important enzyme systems. Substantial evidence implicates BH4 as a key regulator of endothelial nitric oxide synthase (eNOS) in the setting of endothelial dysfunction and atherosclerosis. Investigators have now taken early steps in addressing the potential of BH4 as a therapeutic strategy. However, it has become more apparent that the role of BH4 in other enzymatic pathways, including other NOS isoforms and the aromatic amino acid hydroxylases, may have a bearing on important aspects of cardiovascular homeostasis. Together with eNOS, these enzymes may play key roles in diverse cardiovascular disease states such as ischaemia-reperfusion injury, cardiac hypertrophy, cardiac autonomic function and pulmonary hypertension. This review provides an overview of the role of BH4 in cardiovascular pathophysiology.

引用

页码：1872 / 1877

页数：6

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