Antiviral activity of seed extract from Citrus bergamia towards human retroviruses

被引：63

作者：

Balestrieri, Emanuela ^{[2
]}

Pizzimenti, Francesco ^{[3
]}

Ferlazzo, Angelo ^{[1
]}

Giofre, Salvatore V. ^{[1
]}

Iannazzo, Daniela ^{[1
]}

Piperno, Anna ^{[1
]}

Romeo, Roberto ^{[1
]}

Chiacchio, Maria Assunta ^{[4
]}

Mastino, Antonio ^{[5
,6
]}

Macchi, Beatrice ^{[7
,8
]}

机构：

[1] Univ Messina, Dept Farmacochim, I-98168 Messina, Italy

[2] Univ Roma Tor Vergata, Dept Expt Med & Biochem Sci, I-00133 Rome, Italy

[3] Univ Messina, Dept Farmacobiol, I-98168 Messina, Italy

[4] Univ Catania, Dept Sci Chim, I-95125 Catania, Italy

[5] Univ Messina, Dept Life Sci, I-98166 Messina, Italy

[6] IRCCS Ctr Neurolesi Bonino Pulejo, Messina, Italy

[7] Univ Roma Tor Vergata, Dept Neurosci, I-00133 Rome, Italy

[8] IRCCS Santa Lucia, Rome, Italy

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2011年 / 19卷 / 06期

关键词：

Natural products; Bergamot; Limonoids; Antiretrovirals; HIV; HTLV-1; Reverse transcriptase; HUMAN-IMMUNODEFICIENCY-VIRUS; BLOOD MONONUCLEAR-CELLS; MURINE LEUKEMIA-VIRUS; ANTI-AIDS AGENTS; IN-VITRO; REVERSE-TRANSCRIPTASE; HIV-1; REPLICATION; TYPE-1; INFECTION; ACID; ANALOGS;

D O I：

10.1016/j.bmc.2011.01.024

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effects of an extract from Citrus bergamia (BSext) and those of two products purified from the same extract, that is, nomilin and limonin, and reference compounds, towards HTLV-1 have been reported. Moreover, they were also compared with those obtained towards HIV-1. Results showed that the efficacy of both BSext and limonin in inhibiting HTLV-1 as well as HIV-1 expression in infected cells, as evaluated by comparable quantitative assays, was close to that of the effective, reference compounds, respectively. The protective effect of BSext and of the purified products was associated with the inhibition of both HTLV-1 and HIV-1 RT activities in conceptually similar, cell-free assays. The cytotoxicity of the assayed compounds of natural origin was substantially less pronounced than that of the reference compounds, thus showing a favourable selectivity index for the novel BSext product. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：2084 / 2089

页数：6

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