Effects of Steroids on Thrombogenic Markers in Patients Undergoing Unilateral Total Knee Arthroplasty: A Prospective, Double-Blind, Randomized Controlled Trial

Venous thromboembolism (VTE) remains an important complication after total knee arthroplasty (TKA). Systemic thrombin generation starts perioperatively. Inflammation, characterized by a rise in interleukin-6 (IL6), initiates the coagulation cascade, but low-dose steroids can reduce post-TKA IL6 levels. This double-blinded, randomized, placebo-controlled study enrolled 30 patients undergoing unilateral TKA to assess the effect of perioperative steroids on serum prothrombin fragment (PF1.2), a marker of thrombin generation, and plasmin-alpha-2-antiplasmin complex (PAP), a marker of fibrinolysis. Study patients received 100mg of intravenous hydrocortisone 2h prior to surgery, and controls received normal saline. Blood samples, drawn pre-incision and at 4h post tourniquet release, were assayed for PF1.2 and PAP. The study group had significantly lower mean PF1.2 at 4h compared to controls (616 +/- 358pMol/L vs. 936 +/- 332pMol/L, p=0.037). The mean rise in PF1.2 in the control group was significantly greater compared to the study group (672 +/- 173pMol/L vs. 350 +/- 211pMol/L, p<0.001). Mean PAP was higher in the study group at 4h (1639 +/- 823 mu g/L vs. 1087 +/- 536 mu g/L), but did not reach statistical significance (p=0.07). These results may have clinical implications in terms of postoperative VTE risk and management. (c) 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 33:???-???, 2015.