Mitochondrial control of immunity: beyond ATP

被引：298

作者：

Mehta, Manan M. ^{[1
]}

Weinberg, Samuel E. ^{[1
]}

Chandel, Navdeep S. ^{[1
]}

机构：

[1] Northwestern Univ, Dept Med, Feinberg Sch Med, 240 East Huron Ave,M-334, Chicago, IL 60611 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2017年 / 17卷 / 10期

基金：

美国国家卫生研究院;

关键词：

T-CELL-ACTIVATION; NLRP3 INFLAMMASOME ACTIVATION; FATTY-ACID OXIDATION; REGULATORY T; SUCCINATE-DEHYDROGENASE; MACROPHAGE POLARIZATION; TUMOR MICROENVIRONMENT; PYRUVATE-DEHYDROGENASE; BACTERICIDAL ACTIVITY; METABOLIC CHECKPOINT;

D O I：

10.1038/nri.2017.66

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mitochondria are important signalling organelles, and they dictate immunological fate. From T cells to macrophages, mitochondria form the nexus of the various metabolic pathways that define each immune cell subset. In this central position, mitochondria help to control the various metabolic decision points that determine immune cell function. In this Review, we discuss how mitochondrial metabolism varies across different immune cell subsets, how metabolic signalling dictates cell fate and how this signalling could potentially be targeted therapeutically. © 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.

引用

页码：608 / 620

页数：13

共 125 条

[31]

Garaude J., NAT IMMUNOL, V17, P1

[32] Metabolomics of B to Plasma Cell Differentiation [J].

Garcia-Manteiga, Jose Manuel ;

Mari, Silvia ;

Godejohann, Markus ;

Spraul, Manfred ;

Napoli, Claudia ;

Cenci, Simone ;

Musco, Giovanna ;

Sitia, Roberto .

JOURNAL OF PROTEOME RESEARCH, 2011, 10 (09) :4165-4176

[33] Manipulating the Bioenergetics of Alloreactive T Cells Causes Their Selective Apoptosis and Arrests Graft-Versus-Host Disease [J].

Gatza, Erin ;

Wahl, Daniel R. ;

Opipari, Anthony W. ;

Sundberg, Thomas B. ;

Reddy, Pavan ;

Liu, Chen ;

Glick, Gary D. ;

Ferrara, James L. M. .

SCIENCE TRANSLATIONAL MEDICINE, 2011, 3 (67)

[34] L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity [J].

Geiger, Roger ;

Rieckmann, Jan C. ;

Wolf, Tobias ;

Basso, Camilla ;

Feng, Yuehan ;

Fuhrer, Tobias ;

Kogadeeva, Maria ;

Picotti, Paola ;

Meissner, Felix ;

Mann, Matthias ;

Zamboni, Nicola ;

Sallusto, Federica ;

Lanzavecchia, Antonio .

CELL, 2016, 167 (03) :829-+

[35] Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression [J].

Gerriets, Valerie A. ;

Kishton, Rigel J. ;

Johnson, Marc O. ;

Cohen, Sivan ;

Siska, Peter J. ;

Nichols, Amanda G. ;

Warmoes, Marc O. ;

de Cubas, Aguirre A. ;

Maclver, Nancie J. ;

Locasale, Jason W. ;

Turka, Laurence A. ;

Wells, Andrew D. ;

Rathmell, Jeffrey C. .

NATURE IMMUNOLOGY, 2016, 17 (12) :1459-1466

[36] Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation [J].

Gerriets, Valerie A. ;

Kishton, Rigel J. ;

Nichols, Amanda G. ;

Macintyre, Andrew N. ;

Inoue, Makoto ;

Ilkayeva, Olga ;

Winter, Peter S. ;

Liu, Xiaojing ;

Priyadharshini, Bhavana ;

Slawinska, Marta E. ;

Haeberli, Lea ;

Huck, Catherine ;

Turka, Laurence A. ;

Wood, Kris C. ;

Hale, Laura P. ;

Smith, Paul A. ;

Schneider, Martin A. ;

MacIver, Nancie J. ;

Locasale, Jason W. ;

Newgard, Christopher B. ;

Shinohara, Mari L. ;

Rathmell, Jeffrey C. .

JOURNAL OF CLINICAL INVESTIGATION, 2015, 125 (01) :194-207

[37] Lactate Regulates Metabolic and Proinflammatory Circuits in Control of T Cell Migration and Effector Functions [J].

Haas, Robert ;

Smith, Joanne ;

Rocher-Ros, Vidalba ;

Nadkarni, Suchita ;

Montero-Melendez, Trinidad ;

D'Acquisto, Fulvio ;

Bland, Elliot J. ;

Bombardieri, Michele ;

Pitzalis, Costantino ;

Perretti, Mauro ;

Marelli-Berg, Federica M. ;

Mauro, Claudio .

PLOS BIOLOGY, 2015, 13 (07)

[38] Immunoresponsive Gene 1 Augments Bactericidal Activity of Macrophage-Lineage Cells by Regulating β-Oxidation-Dependent Mitochondrial ROS Production [J].

Hall, Christopher J. ;

Boyle, Rachel H. ;

Astin, Jonathan W. ;

Flores, Maria Vega ;

Oehlers, Stefan H. ;

Sanderson, Leslie E. ;

Ellett, Felix ;

Lieschke, Graham J. ;

Crosier, Kathryn E. ;

Crosier, Philip S. .

CELL METABOLISM, 2013, 18 (02) :265-278

[39] The Sedoheptulose Kinase CARKL Directs Macrophage Polarization through Control of Glucose Metabolism [J].

Haschemi, Arvand ;

Kosma, Paul ;

Gille, Lars ;

Evans, Charles R. ;

Burant, Charles F. ;

Starkl, Philipp ;

Knapp, Bernhard ;

Haas, Robert ;

Schmid, Johannes A. ;

Jandl, Christoph ;

Amir, Shahzada ;

Lubec, Gert ;

Park, Jaehong ;

Esterbauer, Harald ;

Bilban, Martin ;

Brizuela, Leonardo ;

Pospisilik, J. Andrew ;

Otterbein, Leo E. ;

Wagner, Oswald .

CELL METABOLISM, 2012, 15 (06) :813-826

[40] Immunological mechanisms of the antitumor effects of supplemental oxygenation [J].

Hatfield, Stephen M. ;

Kjaergaard, Jorgen ;

Lukashev, Dmitriy ;

Schreiber, Taylor H. ;

Belikoff, Bryan ;

Abbott, Robert ;

Sethumadhavan, Shalini ;

Philbrook, Phaethon ;

Ko, Kami ;

Cannici, Ryan ;

Thayer, Molly ;

Rodig, Scott ;

Kutok, Jeffrey L. ;

Jackson, Edwin K. ;

Karger, Barry ;

Podack, Eckhard R. ;

Ohta, Akio ;

Sitkovsky, Michail V. .

SCIENCE TRANSLATIONAL MEDICINE, 2015, 7 (277)

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