Mitochondrial control of immunity: beyond ATP

被引：298

作者：

Mehta, Manan M. ^{[1
]}

Weinberg, Samuel E. ^{[1
]}

Chandel, Navdeep S. ^{[1
]}

机构：

[1] Northwestern Univ, Dept Med, Feinberg Sch Med, 240 East Huron Ave,M-334, Chicago, IL 60611 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2017年 / 17卷 / 10期

基金：

美国国家卫生研究院;

关键词：

T-CELL-ACTIVATION; NLRP3 INFLAMMASOME ACTIVATION; FATTY-ACID OXIDATION; REGULATORY T; SUCCINATE-DEHYDROGENASE; MACROPHAGE POLARIZATION; TUMOR MICROENVIRONMENT; PYRUVATE-DEHYDROGENASE; BACTERICIDAL ACTIVITY; METABOLIC CHECKPOINT;

D O I：

10.1038/nri.2017.66

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mitochondria are important signalling organelles, and they dictate immunological fate. From T cells to macrophages, mitochondria form the nexus of the various metabolic pathways that define each immune cell subset. In this central position, mitochondria help to control the various metabolic decision points that determine immune cell function. In this Review, we discuss how mitochondrial metabolism varies across different immune cell subsets, how metabolic signalling dictates cell fate and how this signalling could potentially be targeted therapeutically. © 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.

引用

页码：608 / 620

页数：13

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