IL-4 dysregulates microRNAs involved in inflammation, angiogenesis and apoptosis in epidermal keratinocytes

被引：12
作者：
Bao, Lei [1 ]
Chau, Cecilia [2 ]
Bao, Jeremy [1 ]
Tsoukas, Maria M. [1 ]
Chan, Lawrence S. [1 ,3 ,4 ]
机构：
[1] Univ Illinois, Dept Dermatol, RM 338,MC624,808 S Wood St, Chicago, IL 60612 USA
[2] Univ Illinois, Res Resources Ctr, 832 South Wolcott Ave, Chicago, IL USA
[3] Jesse Brown Vet Affairs Hosp, Med Serv, 820 S Damen Ave, Chicago, IL 60612 USA
[4] Captain James A Lovell Fed Hlth Care Ctr, Med Serv, 3001 Green Bay Rd, N Chicago, IL 60064 USA
来源：
MICROBIOLOGY AND IMMUNOLOGY | 2018年 / 62卷 / 11期
关键词：
atopic dermatitis; IL-4; keratinocytes; microRNA; REGULATES CELL-PROLIFERATION; ATOPIC-DERMATITIS; TRANSGENIC MICE; PATHOGENESIS; EXPRESSION; DISEASE; GROWTH; CANCER; GENES;
D O I：
10.1111/1348-0421.12650
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
IL-4 plays an important role in the pathogenesis of atopic dermatitis (AD) by dysregulating many key factors at the transcriptional level. In this study, a microRNA array technique and IL-4 transgenic mice were used to demonstrate that IL-4 dysregulates microRNAs involved in inflammation, angiogenesis, lymphangiogenesis and apoptosis. Of the 372 common microRNAs examined, 26 and one microRNAs were found to be up- and down-regulated, respectively. MicroRNA-101-5p, -122-5p, -142-3p, -204-5p, -335-3p, -376a-3p, -378a-5p, -639 and -9-5p are among the most significantly up-regulated microRNAs. MicroRNA-147a, the only one that was down- regulated in the present study, attenuates TLR-induced inflammatory responses. These dysregulated microRNAs may provide post-transcriptional regulation of key genes in AD.
引用
收藏
页码：732 / 736
页数：5
相关论文
共 22 条
[1]   A molecular mechanism for IL-4 suppression of loricrin transcription in epidermal keratinocytes: implication for atopic dermatitis pathogenesis [J].
Bao, Lei ;
Mohan, Girish C. ;
Alexander, Jaime B. ;
Doo, Caroline ;
Shen, Kui ;
Bao, Jeremy ;
Chan, Lawrence S. .
INNATE IMMUNITY, 2017, 23 (08) :641-647
[2]   Differential expression of inflammation-related genes in IL-4 transgenic mice before and after the onset of atopic dermatitis skin lesions [J].
Bao, Lei ;
Zhang, Huayi ;
Mohan, Girish C. ;
Shen, Kui ;
Chan, Lawrence S. .
MOLECULAR AND CELLULAR PROBES, 2016, 30 (01) :30-38
[3]   IL-4 up-regulates epidermal chemotactic, angiogenic, and pro-inflammatory genes and down-regulates antimicrobial genes in vivo and in vitro: Relevant in the pathogenesis of atopic dermatitis [J].
Bao, Lei ;
Shi, Vivian Y. ;
Chan, Lawrence S. .
CYTOKINE, 2013, 61 (02) :419-425
[4]   MicroRNA signature of inflamed lymphatic endothelium and role of miR-9 in lymphangiogenesis and inflammation [J].
Chakraborty, Sanjukta ;
Zawieja, David C. ;
Davis, Michael J. ;
Muthuchamy, Mariappan .
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2015, 309 (10) :C680-C692
[5]   Expression of interleukin-4 in the epidermis of transgenic mice results in a pruritic inflammatory skin disease: An experimental animal model to study atopic dermatitis [J].
Chan, LS ;
Robinson, N ;
Xu, LT .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2001, 117 (04) :977-983
[6]   MicroRNA-132 and microRNA-223 control positive feedback circuit by regulating FOXO3a in inflammatory bowel disease [J].
Kim, Hye-Youn ;
Kwon, Hyeok Yi ;
Thi, Huyen Trang Ha ;
Lee, Ho Jae ;
Kim, Gwang Il ;
Hahm, Ki-Baek ;
Hong, Suntaek .
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2016, 31 (10) :1727-1735
[7]   The Role of miR-378a in Metabolism, Angiogenesis, and Muscle Biology [J].
Krist, Bart ;
Florczyk, Urszula ;
Pietraszek-Gremplewicz, Katarzyna ;
Jozkowicz, Alicja ;
Dulak, Jozef .
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY, 2015, 2015
[8]   Tumor suppressor miRNA-204-5p promotes apoptosis by targeting BCL2 in prostate cancer cells [J].
Lin, Yi-Chia ;
Lin, Ji-Fan ;
Tsai, Te-Fu ;
Chou, Kuang-Yu ;
Chen, Hung-En ;
Hwang, Thomas I-Sheng .
ASIAN JOURNAL OF SURGERY, 2017, 40 (05) :396-406
[9]   miR-639 regulates transforming growth factor beta-induced epithelial-mesenchymal transition in human tongue cancer cells by targeting FOXC1 [J].
Lin, Zhaoyu ;
Sun, Lijuan ;
Chen, Weiliang ;
Liu, Bodu ;
Wang, Youyuan ;
Fan, Song ;
Li, Yilin ;
Li, Jinsong .
CANCER SCIENCE, 2014, 105 (10) :1288-1298
[10]   RETRACTED: MicroRNA-30d promotes angiogenesis and tumor growth via MYPT1/c-JUN/VEGFA pathway and predicts aggressive outcome in prostate cancer (Retracted Article) [J].
Lin, Zhuo-yuan ;
Chen, Guo ;
Zhang, Yan-qiong ;
He, Hui-chan ;
Liang, Yu-xiang ;
Ye, Jian-heng ;
Liang, Ying-ke ;
Mo, Ru-jun ;
Lu, Jian-ming ;
Zhuo, Yang-jia ;
Zheng, Yu ;
Jiang, Fu-neng ;
Han, Zhao-dong ;
Wu, Shu-lin ;
Zhong, Wei-de ;
Wu, Chin-lee .
MOLECULAR CANCER, 2017, 16
123