Coxibs, Traditional NSAIDs, and Cardiovascular Safety Post-PRECISION: What We Thought We Knew Then and What We Think We Know Now

被引：30

作者：

Patrono, C. ^{[1
]}

Baigent, C. ^{[2
,3
,4
]}

机构：

[1] Catholic Univ, Sch Med, Dept Pharmacol, Rome, Italy

[2] Univ Oxford, Nuffield Dept Populat Hlth, Med Res Council, Populat Hlth Res Unit, Oxford, England

[3] Univ Oxford, Nuffield Dept Populat Hlth, Clin Trial Serv Unit, Oxford, England

[4] Univ Oxford, Nuffield Dept Populat Hlth, Epidemiol Studies Unit, Oxford, England

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2017年 / 102卷 / 02期

关键词：

NONSTEROIDAL ANTIINFLAMMATORY DRUGS; LOW-DOSE ASPIRIN; CYCLOOXYGENASE INHIBITION; GASTROINTESTINAL TOXICITY; CLINICAL-PHARMACOLOGY; PLATELET-FUNCTION; CELECOXIB; NAPROXEN; PROSTACYCLIN; THROMBOXANE;

D O I：

10.1002/cpt.696

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The aim of the present review is to analyze how thinking about the cardiovascular safety of nonsteroidal antiinflammatory drugs has evolved during the past two decades, and discuss to what extent the additional information from the Prospective Randomized Evaluation of Celecoxib Integrated Safety Versus Ibuprofen or Naproxen study may alter our current mechanistic understanding and/or clinical practice.

引用

页码：238 / 245

页数：8

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