Protective effects of edaravone combined puerarin on inhalation lung injury induced by black gunpowder smog

被引：10
作者：
Wang, Zhengguan [1 ,2 ]
Li, Ruibing [1 ]
Liu, Yifan [1 ]
Liu, Xiaoting [1 ]
Chen, Wenyan [1 ]
Xu, Shumin [1 ]
Guo, Yuni [1 ]
Duan, Jinyang [1 ]
Chen, Yihong [2 ]
Wang, Chengbin [1 ]
机构：
[1] Chinese Peoples Liberat Army Gen Hosp, Dept Clin Lab, Beijing 700853, Peoples R China
[2] Chinese Peoples Liberat Army Gen Hosp, Dept Med Secur, Beijing 100853, Peoples R China
来源：
INTERNATIONAL IMMUNOPHARMACOLOGY | 2015年 / 26卷 / 01期
关键词：
Inhalation lung injury; Edaravone; Puerarin; Black gunpowder smog; FREE-RADICAL SCAVENGER; KAPPA-B; PULMONARY COMPLICATIONS; RATS; ISCHEMIA/REPERFUSION; INTERLEUKIN-8; INFLAMMATION; NEUTROPHILS; ACTIVATION; INHIBITION;
D O I：
10.1016/j.intimp.2015.02.034
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Objective: The present study aimed to investigate the combined effects of puerarin with edaravone on inhalation lung injury induced by black gunpowder smog. Materials and methods: Male Wistar rats were divided into five groups (control group, edaravone group, puerarin group, edaravone combined with puerarin group and inhalation group). The severity of pulmonary injuries was evaluated after inducing acute lung injury. Arterial blood gas, inflammatory cytokines, biochemical, parameters, cell counting, W/D weight ratio and histopathology were analyzed. Results in lung tissues, either edaravone or puerarin treatment alone showed significant protective effects against neutrophil infiltration and tissue injury, as demonstrated by myeloperoxidase activity and histopathological analysis (all p < 0.05). In addition, combined treatment with both edaravone and puerarin demonstrated additive protective effects on smog-induced lung injury, compared with single treatment Conclusions: Combination of edaravone and puerarin shows promise as a new treatment option for acute lung injury/acute respiratory distress syndrome patients. (C) 2015 Elsevier B.V. All rights reserved.
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收藏
页码：125 / 132
页数：8
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