Ellagic Acid and Its Anti-Aging Effects on Central Nervous System

被引：45
作者：
Zhu, Heyu [1 ]
Yan, Yuanmei [1 ]
Jiang, Yi [1 ]
Meng, Xianfang [1 ]
机构：
[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Basic Med Sci, Dept Neurobiol, Wuhan 430030, Peoples R China
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 18期
基金：
中国国家自然科学基金;
关键词：
ellagic acid; anti-aging; anti-inflammation; antioxidant; neuroprotection; OXIDATIVE STRESS; PARKINSONS-DISEASE; ALZHEIMERS-DISEASE; RAT MODEL; INFLAMMATION; ACTIVATION; PATHWAYS; STROKE; CANCER; ALPHA;
D O I：
10.3390/ijms231810937
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Aging is an unavoidable biological process that leads to the decline of human function and the reduction in people's quality of life. Demand for anti-aging medicines has become very urgent. Many studies have shown that ellagic acid (EA), a phenolic compound widely distributed in dicotyledonous plants, has powerful anti-inflammation and antioxidant properties. Moreover, it has been demonstrated that EA can enhance neuronal viability, reduce neuronal defects, and alleviate damage in neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and cerebral ischemia. This paper reviews the biochemical functions and neuroprotective effects of EA, showing the clinical value of its application.
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页数：11
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