A highly stereoselective synthesis of (2S,3S)-beta-hydroxyleucine

被引：28

作者：

Laib, T ^{[1
]}

Chastanet, J ^{[1
]}

Zhu, JP ^{[1
]}

机构：

[1] CNRS,INST CHIM SUBST NAT,F-91198 GIF SUR YVETTE,FRANCE

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 10期

关键词：

ALPHA-AMINO-ACIDS; ASYMMETRIC-SYNTHESIS; ORGANIC-SYNTHESIS; (2S; 3S)-3-HYDROXYLEUCINE; (2R; 3R)-3-HYDROXYLEUCINE; CONVERSION; ALDEHYDES;

D O I：

10.1016/S0040-4039(97)00207-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly diastereoselective nucleophilic addition of Grignard reagent to N,N-dibenzyl-O-TBS-serinal 3 was the key step in the present synthesis of(2S,3s)-beta-hydroxyleucine 1. (C) 1997 Published by Elsevier Science Ltd.

引用

页码：1771 / 1772

页数：2

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