A highly stereoselective synthesis of (2S,3S)-beta-hydroxyleucine

被引：28
|
作者：
Laib, T [1 ]
Chastanet, J [1 ]
Zhu, JP [1 ]
机构：
[1] CNRS,INST CHIM SUBST NAT,F-91198 GIF SUR YVETTE,FRANCE
来源：
TETRAHEDRON LETTERS | 1997年 / 38卷 / 10期
关键词：
ALPHA-AMINO-ACIDS; ASYMMETRIC-SYNTHESIS; ORGANIC-SYNTHESIS; (2S; 3S)-3-HYDROXYLEUCINE; (2R; 3R)-3-HYDROXYLEUCINE; CONVERSION; ALDEHYDES;
D O I：
10.1016/S0040-4039(97)00207-4
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A highly diastereoselective nucleophilic addition of Grignard reagent to N,N-dibenzyl-O-TBS-serinal 3 was the key step in the present synthesis of(2S,3s)-beta-hydroxyleucine 1. (C) 1997 Published by Elsevier Science Ltd.
引用
收藏
页码：1771 / 1772
页数：2
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