Due to intravascular multiple sequential scattering, Diffuse Correlation Spectroscopy of tissue primarily measures relative red blood cell motion within vessels

被引：46

作者：

Carp, Stefan A. ^{[1
]}

Roche-Labarbe, Nadege ^{[1
]}

Franceschini, Maria-Angela ^{[1
]}

Srinivasan, Vivek J. ^{[1
]}

Sakadzic, Sava ^{[1
]}

Boas, David A. ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USA

来源：

BIOMEDICAL OPTICS EXPRESS | 2011年 / 2卷 / 07期

关键词：

WAVE SPECTROSCOPY; FLOW; ARTERIAL; HEMATOCRIT; VALIDATION; MODEL;

D O I：

10.1364/BOE.2.002047

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

We suggest that Diffuse Correlation Spectroscopy (DCS) measurements of tissue blood flow primarily probe relative red blood cell (RBC) motion, due to the occurrence of multiple sequential scattering events within blood vessels. The magnitude of RBC shear-induced diffusion is known to correlate with flow velocity, explaining previous reports of linear scaling of the DCS "blood flow index" with tissue perfusion despite the observed diffusion-like auto-correlation decay. Further, by modeling RBC mean square displacement using a formulation that captures the transition from ballistic to diffusive motion, we improve the fit to experimental data and recover effective diffusion coefficients and velocity de-correlation time scales in the range expected from previous blood rheology studies. (C) 2011 Optical Society of America

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页码：2047 / 2054

页数：8

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