Novel Copper Bearing Schiff Bases with Photodynamic Anti-Inflammatory and Anti-Microbial Activities

被引：12

作者：

Ayaz, Furkan ^{[1
]}

Gonul, Ilyas ^{[2
]}

Demirbag, Burcu ^{[1
]}

Ocakoglu, Kasim ^{[3
]}

机构：

[1] Mersin Univ, Fac Arts & Sci, Dept Biotechnol, TR-33110 Mersin, Turkey

[2] Cukurova Univ, Fac Arts & Sci, Dept Chem, TR-01330 Adana, Turkey

[3] Tarsus Univ, Fac Technol, Dept Energy Syst Engn, TR-33400 Tarsus, Turkey

来源：

APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY | 2020年 / 191卷 / 02期

关键词：

Inflammation; Macrophage; Immunomodulation; Anti-inflammatory molecules; Anti-microbial activity; MURINE MACROPHAGE; IN-VITRO; IMMUNITY; INFLAMMATION; CANCER; COMPLEXES; LIGANDS; CELLS; IMMUNOMODULATION; CYTOKINES;

D O I：

10.1007/s12010-019-03223-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Schiff bases and their copper complexes have been previously studied for their anti-inflammatory, anti-tumor as well as anti-microbial activities. Schiff bases can be derivatized to gain photoluminiscence capacity. This property of the schiff bases enables the transfer of the electrons upon absorption of the light at a specific wavelength. In this study, we exploited this attribute of novel copper bearing schiff bases and tested their photodynamic biological activities. These compounds exerted photodynamic anti-inflammatory activities on the in vitro activated mammalian macrophages. Compared with salicylic acid control groups, these novel schiff bases had stronger activity which became more prominent with photo-induction. Moreover, they also had anti-microbial activity on gram negative bacteria E.coli and gram positive bacteria S.aureus.This anti-microbial activity was stronger than that of Neomycin on both bacterial strains. Our results suggest their potential use as anti-inflammatory and anti-microbial agents both in the dark as well as after photo-induction.

引用

页码：716 / 727

页数：12

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