Adult Neurogenesis in Neurodegenerative Diseases

被引：233

作者：

Winner, Beate ^{[1
]}

Winkler, Juergen ^{[2
]}

机构：

[1] FAU Erlangen Nurnberg, Nikolaus Fiebiger Ctr Mol Med, Interdisciplinary Ctr Clin Res, IZKF Jr Res Grp 3, D-91054 Erlangen, Germany

[2] FAU Erlangen Nurnberg, Dept Mol Neurol, D-91054 Erlangen, Germany

来源：

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY | 2015年 / 7卷 / 04期

关键词：

PROGENITOR-CELL PROLIFERATION; TRANSGENIC MOUSE MODEL; HUNTINGTONS-DISEASE; ALPHA-SYNUCLEIN; HIPPOCAMPAL NEUROGENESIS; PARKINSONS-DISEASE; ALZHEIMERS-DISEASE; ENVIRONMENTAL ENRICHMENT; SUBVENTRICULAR ZONE; MUTANT HUNTINGTIN;

D O I：

10.1101/cshperspect.a021287

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Adult neurogenesis is limited to specific brain regions in the mammalian brain, such as the hippocampal dentate gyrus and the subventricular zone/olfactory bulb system. Alterations in adult neurogenesis appear to be a common hallmark in different neurodegenerative diseases including Parkinson's disease (PD), Alzheimer's disease (AD), and Huntington's disease (HD). This is remarkable, because the distinct pathological proteins responsible for the different diseases induce the loss of different neural populations. Impaired adult neurogenesis was shown in numerous animal models of neurodegenerative diseases; however, only few postmortem studies have been performed. We will review concepts related to the interplay between cellular plasticity in regions of adult neurogenesis with a specific focus on cell-autonomous and non-cell-autonomous factors. Furthermore, various strategies aimed to stimulate neuronal plasticity will be discussed within the context of a potential translation into therapeutic approaches for neuropsychiatric symptoms associated with PD, HD, and AD.

引用

页数：14

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