Synthesis of cyanopyridine and pyrimidine analogues as new anti-inflammatory and antimicrobial agents

被引：47
|
作者：
Kumar, Nitin [1 ]
Chauhan, Alka [1 ]
Drabu, Sushma [2 ]
机构：
[1] MIET, Pharmaceut Chem Res Lab, Meerut 250005, Uttar Pradesh, India
[2] Maharaja Surajmal Inst Pharm, New Delhi, India
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2011年 / 65卷 / 05期
关键词：
Cyanopyridine; Pyrimidine; Anti-inflammatory activity and antimicrobial activity;
D O I：
10.1016/j.biopha.2011.04.023
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
A new series of substituted benzylidene acetophenone (Ia-Ih), 2-amino-4, 6- substituted diphenylpyridine-3-carbonitrile (IIa-IIh) and 4, 6-substituted diphenylpyrimidin-2-amine (IIId-IIIg) were synthesized and evaluated for anti-inflammatory and antimicrobial activities. Four compounds (Ie, If, IIh and IIId) have shown good anti-inflammatory activity when compared to standard drug indomethacin. Two compound (Ie and IIh) displayed significant activity against gram -ve bacteria (E. Coli) and three compounds (IId, IIf and IIIh) displayed good activity against gram +ve bacteria (S. aureus) on comparison with the standard drug ofloxacin. (C) 2011 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：375 / 380
页数：6
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