An efficient and expeditious synthesis of di- and monosubstituted 2-aminoimidazoles

被引：25

作者：

Soh, Chai Hoon ^{[1
]}

Chui, Wai Keung ^{[2
]}

Lam, Yulin ^{[1
]}

机构：

[1] Natl Univ Singapore, Dept Chem, Singapore 117543, Singapore

[2] Natl Univ Singapore, Dept Pharm, Singapore 117543, Singapore

来源：

JOURNAL OF COMBINATORIAL CHEMISTRY | 2008年 / 10卷 / 01期

关键词：

D O I：

10.1021/cc700143n

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A microwave-assisted protocol was developed for the construction of di- and monosubstituted 2-aminoimidazoles. The two-step reaction involves the synthesis of N-(1H-imidazol-2-yl)acetamides from readily available alpha-haloketones and N-acetylguanidine, followed by deacetylation. Significant rate enhancement was observed for both steps of the protocol, and the overall reaction time was shortened to 20 min compared to 48 h of the conventional procedures. A representative set of di- and monosubstituted 2-aminoimidazoles was prepared using commercially available parallel reactors.

引用

页码：118 / 122

页数：5

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