Flow synthesis of secondary amines over Ag/Al2O3 catalyst by one-pot reductive amination of aldehydes with nitroarenes

被引：14

作者：

Artiukha, Ekaterina A. ^{[1
]}

Nuzhdin, Alexey L. ^{[1
]}

Bukhtiyarova, Galina A. ^{[1
]}

Bukhtiyarov, Valerii I. ^{[1
,2
]}

机构：

[1] Boreskov Inst Catalysis SB RAS, Novosibirsk 630090, Russia

[2] Novosibirsk State Univ, Novosibirsk 630090, Russia

来源：

RSC ADVANCES | 2017年 / 7卷 / 72期

关键词：

LIQUID-PHASE HYDROGENATION; CARBONYL-COMPOUNDS; NITRO-COMPOUNDS; AU/AL2O3; CATALYST; RECOVERABLE CATALYST; HIGHLY EFFICIENT; COBALT CATALYST; MILD CONDITIONS; NANOPARTICLES; MONOALKYLATION;

D O I：

10.1039/c7ra08986d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An alumina-supported silver catalyst was investigated in the one-pot reductive amination of aldehydes with nitroarenes in a continuous flow reactor using molecular hydrogen as a reducing agent. A series of secondary amines containing alkyl, OH, OCH3, Cl, Br and C=C groups was synthesized in good to excellent yields. The yield of the secondary amine depends on the rate of formation of an intermediate imine. It was shown that the accumulation of carbonaceous deposits on the catalyst is the main reason of catalyst deactivation. The spent catalyst can be easily regenerated and reused without losing catalytic activity.

引用

页码：45856 / 45861

页数：6

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