Inhibition of Breast Cancer Metastasis Via PITPNM3 by Pachymic Acid

被引：32
作者：
Hong, Ri [1 ]
Shen, Min-He [2 ]
Xie, Xiao-Hong [1 ]
Ruan, Shan-Ming [2 ]
机构：
[1] Zhejiang Chinese Med Univ, Sch Clin Med 1, Dept Breast, Hangzhou, Zhejiang, Peoples R China
[2] Zhejiang Chinese Med Univ, Sch Clin Med 1, Dept Oncol, Hangzhou, Zhejiang, Peoples R China
来源：
ASIAN PACIFIC JOURNAL OF CANCER PREVENTION | 2012年 / 13卷 / 05期
关键词：
Breast cancer; metastasis; MDA-MB-231; PITPNM3; pachymic acid; PORIA-COCOS; CCL18; MACROPHAGES; EXPRESSION; BONE;
D O I：
10.7314/APJCP.2012.13.5.1877
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Breast cancer metastasis is the most common cause of cancer-related death in women. Thus, seeking targets of breast tumor cells is an attractive goal towards improving clinical treatment. The present study showed that CCL18 from tumor-associated macrophages could promote breast cancer metastasis via PITPNM3. In addition, we found that pachymic acid (PA) could dose-dependently inhibit migration and invasion of MDA-MB-231cells, with or without rCCL18 stimulation. Furthermore, evidence was obtained that PA could suppress the phosphorylation of PITPNM3 and the combination of CCL18 and PITPNM3. Therefore, we speculate that PA could inhibit breast cancer metastasis via PITPNM3.
引用
收藏
页码：1877 / 1880
页数：4
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