The role of the c-Jun N-terminal Kinase signaling pathway in skin cancer

被引：0
作者：
Zhang, Jennifer Y. [1 ]
Selim, Maria Angelica [1 ]
机构：
[1] Duke Univ, Dept Dermatol & Pathol, Durham, NC USA
来源：
AMERICAN JOURNAL OF CANCER RESEARCH | 2012年 / 2卷 / 06期
关键词：
JNK; skin cancer; squamous cell carcinoma; basal cell carcinoma; cylindroma;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The c-Jun N-terminal Kinases (JNK), along with Erk and p38, constitute the principle members of the mitogen-activated protein kinase (MAPK) family. JNK functions primarily through AP1 family transcription factors to regulate a plethora of cellular processes, including cell proliferation, differentiation, survival and migration. It also cross-talks and integrates with other signaling pathways in a cell context-specific and cell type-specific manner. The current views of JNK function in various skin cancers and the need of developing JNK subunit-specific inhibitors for cancer type-specific applications have been summarized in this review.
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页码：691 / 698
页数：8
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