Photodynamic therapy for esophageal carcinoma*

被引：6

作者：

Lindenmann, J. ^{[1
]}

Maier, A. ^{[1
]}

Matzi, V. ^{[1
]}

Neuboeck, N. ^{[1
]}

Anegg, U. ^{[1
]}

Porubsky, Ch. ^{[1
]}

Sankin, O. ^{[1
]}

Fell, B. ^{[1
]}

Renner, H. ^{[1
]}

Swatek, P. ^{[1
]}

Smolle-Juettner, F. M. ^{[1
]}

机构：

[1] Med Univ Graz, Dept Surg, Div Thorac & Hyperbar Surg, A-8036 Graz, Austria

来源：

EUROPEAN SURGERY-ACTA CHIRURGICA AUSTRIACA | 2011年 / 43卷 / 06期

关键词：

Esophageal cancer; photodynamic therapy; palliative therapy; dysphagia; quality of life; ENDOSCOPIC MUCOSAL RESECTION; SQUAMOUS-CELL CARCINOMAS; HIGH-GRADE DYSPLASIA; ND-YAG LASER; BARRETTS-ESOPHAGUS; 5-AMINOLEVULINIC ACID; EARLY CANCER; GASTROINTESTINAL NEOPLASMS; GASTROESOPHAGEAL JUNCTION; PHOTORADIATION THERAPY;

D O I：

10.1007/s10353-011-0051-x

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

BACKGROUND: Patients suffering from advanced esophageal cancer ineligible for resection still have a poor prognosis. Photodynamic Therapy (PDT) is a very effective approach in the endoluminal palliative treatment regimen of this malignancy. METHODS: The mechanism of function is based on the illumination of malignant tissue after selective accumulation of photosensitizers in tumour cells resulting in local tumour necrosis. In case of esophageal cancer, PDT is performed endoscopically under general anaesthesia. RESULTS: Significant reduction of the endoluminal tumour associated with increased quality of life can be achieved which helps conditioning the patient for further palliative treatment procedures. CONCLUSIONS: Local endoluminal palliation with the aim to improve swallowing, decrement of dysphagia and therefore improvement of the patient's quality of life are the main therapeutic goals of PDT in case of inoperable esophageal cancer. Therefore, PDT has become a more and more accepted as well as safe, feasible and efficient endoscopic treatment option within the multimodal palliation regimen of advanced esophageal cancer.

引用

页码：355 / 365

页数：11

共 91 条

[1] Photodynamic therapy for dysplastic Barrett's oesophagus: a prospective, double blind, randomised, placebo controlled trial [J].