Chemical profiling of cerebrospinal fluid by multiple reaction monitoring mass spectrometry

被引：24

作者：

Ferreira, Christina R. ^{[1
,2
]}

Yannell, Karen E. ^{[1
,2
]}

Mollenhauer, Brit ^{[3
,4
,5
,6
]}

Espy, Ryan D. ^{[1
,2
]}

Cordeiro, Fernanda B. ^{[1
,2
]}

Ouyang, Z. ^{[7
,8
]}

Cooks, R. G. ^{[1
,2
]}

机构：

[1] Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA

[2] Purdue Univ, CAID, W Lafayette, IN 47907 USA

[3] Paracelsus Elena Klin, Kassel, Germany

[4] Univ Med Ctr Goettingen, Gottingen, Germany

[5] Univ Med Ctr Gottingen, Inst Neuropathol, Gottingen, Germany

[6] Univ Med Ctr Gottingen, Dept Neurosurg, Gottingen, Germany

[7] Purdue Univ, Weldon Sch Biomed Engn, W Lafayette, IN 47907 USA

[8] Purdue Univ, Dept Elect & Comp Engn, W Lafayette, IN 47907 USA

来源：

ANALYST | 2016年 / 141卷 / 18期

关键词：

HUMAN BRAIN-TUMORS; PARKINSONS-DISEASE; HIGH-THROUGHPUT; METABOLOMICS; IONIZATION; DIAGNOSIS;

D O I：

10.1039/c6an01618a

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

We report an accelerated biomarker discovery workflow and results of sample screening by mass spectrometry based on multiple reaction monitoring (MRM). This methodology shows promising initial results for the currently unsolved challenge of Parkinson's disease (PD) laboratory diagnosis by biomarker screening. Small molecules present in cerebrospinal fluid (CSF) at low parts per million levels are monitored using specific transitions connecting ion pairs. A set of such transitions constitutes a multidimensional chemical profile used to distinguish and characterize different CSF samples using multivariate statistical methods.

引用

页码：5252 / 5255

页数：4

共 19 条

[1] Ambient mass spectrometry [J].

Cooks, RG ;

Ouyang, Z ;

Takats, Z ;

Wiseman, JM .

SCIENCE, 2006, 311 (5767) :1566-1570

[2] High-throughput platforms for metabolomics [J].

de Raad, Markus ;

Fischer, Curt R. ;

Northen, Trent R. .

CURRENT OPINION IN CHEMICAL BIOLOGY, 2016, 30 :7-13

[3] Ambient mass spectrometry for the intraoperative molecular diagnosis of human brain tumors [J].

Eberlin, Livia S. ;

Norton, Isaiah ;

Orringer, Daniel ;

Dunn, Ian F. ;

Liu, Xiaohui ;

Ide, Jennifer L. ;

Jarmusch, Alan K. ;

Ligon, Keith L. ;

Jolesz, Ferenc A. ;

Golby, Alexandra J. ;

Santagata, Sandro ;

Agar, Nathalie Y. R. ;

Cooks, R. Graham .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (05) :1611-1616

[4] Cerebrospinal fluid sodium rhythms [J].

Harrington M.G. ;

Salomon R.M. ;

Pogoda J.M. ;

Oborina E. ;

Okey N. ;

Johnson B. ;

Schmidt D. ;

Fonteh A.N. ;

Dalleska N.F. .

Cerebrospinal Fluid Research, 7 (1)

[5] Ambient Sampling/Ionization Mass Spectrometry: Applications and Current Trends [J].

Harris, Glenn A. ;

Galhena, Asiri S. ;

Fernandez, Facundo M. .

ANALYTICAL CHEMISTRY, 2011, 83 (12) :4508-4538

[6] ACCURACY OF CLINICAL-DIAGNOSIS OF IDIOPATHIC PARKINSONS-DISEASE - A CLINICOPATHOLOGICAL STUDY OF 100 CASES [J].

HUGHES, AJ ;

DANIEL, SE ;

KILFORD, L ;

LEES, AJ .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1992, 55 (03) :181-184

[7] Ambient Ionization Mass Spectrometry for Cancer Diagnosis and Surgical Margin Evaluation [J].

Ifa, Demian R. ;

Eberlin, Livia S. .

CLINICAL CHEMISTRY, 2016, 62 (01) :111-123

[8] Lipid and metabolite profiles of human brain tumors by desorption electrospray ionization-MS [J].

Jarmusch, Alan K. ;

Pirro, Valentina ;

Baird, Zane ;

Hattab, Eyas M. ;

Cohen-Gadol, Aaron A. ;

Cooks, R. Graham .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2016, 113 (06) :1486-1491

[9] CSF biomarkers associated with disease heterogeneity in early Parkinson's disease: the Parkinson's Progression Markers Initiative study [J].

Kang, Ju-Hee ;

Mollenhauer, Brit ;

Coffey, Christopher S. ;

Toledo, Jon B. ;

Weintraub, Daniel ;

Galasko, Douglas R. ;

Irwin, David J. ;

Van Deerlin, Vivianna ;

Chen-Plotkin, Alice S. ;

Caspell-Garcia, Chelsea ;

Waligorska, Teresa ;

Taylor, Peggy ;

Shah, Nirali ;

Pan, Sarah ;

Zero, Pawel ;

Frasier, Mark ;

Marek, Kenneth ;

Kieburtz, Karl ;

Jennings, Danna ;

Tanner, Caroline M. ;

Simuni, Tanya ;

Singleton, Andrew ;

Toga, Arthur W. ;

Chowdhury, Sohini ;

Trojanowski, John Q. ;

Shaw, Leslie M. .

ACTA NEUROPATHOLOGICA, 2016, 131 (06) :935-949

[10] L-Glutamate, L-arginine and L-citrulline levels in cerebrospinal fluid of Parkinson's disease, multiple system atrophy, and Alzheimer's disease patients [J].

Kuiper, MA ;

Teerlink, T ;

Visser, JJ ;

Bergmans, PLM ;

Scheltens, P ;

Wolters, EC .

JOURNAL OF NEURAL TRANSMISSION, 2000, 107 (02) :183-189

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