MicroRNA-542-5p as a novel tumor suppressor in neuroblastoma

被引：80

作者：

Bray, Isabella ^{[1
,2
]}

Tivnan, Amanda ^{[1
,2
]}

Bryan, Kenneth ^{[1
,2
]}

Foley, Niamh H. ^{[1
,2
]}

Watters, Karen M. ^{[1
,2
]}

Tracey, Lorraine ^{[3
]}

Davidoff, Andrew M. ^{[3
,4
]}

Stallings, Raymond L. ^{[1
,2
]}

机构：

[1] Royal Coll Surgeons Ireland, Dept Canc Genet, Dublin 2, Ireland

[2] Our Ladys Childrens Hospital, Childrens Res Ctr, Dublin 12, Ireland

[3] St Jude Childrens Hosp, Dept Surg, Memphis, TN 38105 USA

[4] Univ Tennessee, Hlth Sci Ctr, Dept Surg, Memphis, TN 38105 USA

来源：

CANCER LETTERS | 2011年 / 303卷 / 01期

基金：

爱尔兰科学基金会;

关键词：

MicroRNAs; Neuroblastoma; miR-542-5p; Orthotopic mouse model; MURINE MODEL; EXPRESSION; PROLIFERATION; NORMALIZATION; APOPTOSIS; PATTERNS; MIR-34A; CELLS; GENE;

D O I：

10.1016/j.canlet.2011.01.016

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Several studies have implicated the dysregulation of microRNAs in neuroblastoma pathogenesis, an often fatal paediatric cancer arising from precursor cells of the sympathetic nervous system. Our group and others have demonstrated that lower expression of miR-542-5p is highly associated with poor patient survival, indicating a potential tumor suppressive function. Here, we demonstrate that ectopic over-expression of this miRNA decreases the invasive potential of neuroblastoma cell lines in vitro, along with primary tumor growth and metastases in an orthotopic mouse xenograft model, providing the first functional evidence for the involvement of miR-542-5p as a tumor suppressor in any type of cancer. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

引用

页码：56 / 64

页数：9

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