The utility of the transtubular potassium gradient in the evaluation of hyperkalemia

被引：64

作者：

Choi, Michael J. ^{[2
]}

Ziyadeh, Fuad N. ^{[1
,3
]}

机构：

[1] Amer Univ Beirut, Dept Internal Med, Fac Med, Beirut, Lebanon

[2] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA

[3] Amer Univ Beirut, Dept Physiol, Fac Med, Beirut, Lebanon

来源：

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | 2008年 / 19卷 / 03期

关键词：

D O I：

10.1681/ASN.2007091017

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The transtubular potassium gradient (TTKG) is used to gauge renal potassium secretion by the cortical collecting duct, indirectly assessing mineralocorticoid bioactivity in patients who have hypo- or hyperkalemia. TTKG values < 6 indicate an inappropriate renal response to hyperkalemia, whereas values > 2 during hypokalemia point to renal loss. Hypokalemia is not addressed here. Studies supporting the usefulness of the TTKG in hyperkalemia are limited to case series. This calculation may be most useful in distinguishing hyperkalemic patients who have mineralocorticoid deficiency versus resistance by observing a change in TTKG values after physiologic or pharmacologic doses of mineralocorticoids.

引用

页码：424 / 426

页数：3

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