The role of microtubule-associated protein 1B in axonal growth and neuronal migration in the central nervous system

被引:0
作者
Yang, Maoguang [1 ]
Wu, Minfei [1 ]
Xia, Peng [1 ]
Wang, Chunxin [1 ]
Yan, Peng [1 ]
Gao, Qi [1 ]
Liu, Jian [1 ]
Wang, Haitao [1 ]
Duan, Xingwei [1 ]
Yang, Xiaoyu [1 ]
机构
[1] Jilin Univ, China Japan Union Hosp, Dept Orthoped, Changchun 130033, Jilin Province, Peoples R China
基金
中国国家自然科学基金;
关键词
microtubule-associated protein 1B; central nervous system; axonal regeneration; axonal development; axon guidance; neuronal migration; GROWING AXONS; PHOSPHORYLATED MAP1B; HEAVY-CHAIN; KINASE; EXPRESSION; CONE; STABILIZATION; REGENERATION; OUTGROWTH; GUIDANCE;
D O I
10.3969/j.issn.1673-5374.2012.11.098
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
In this review, we discuss the role of microtubule-associated protein 18 (MAP1B) and its phosphorylation in axonal development and regeneration in the central nervous system. MAP1B exhibits similar functions during axonal development and regeneration. MAP1B and phosphorylated MAP1B in neurons and axons maintain a dynamic balance between cytoskeletal components, and regulate the stability and interaction of microtubules and actin to promote axonal growth, neural connectivity and regeneration in the central nervous system.
引用
收藏
页码:842 / 848
页数:7
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