Imaging efficiency of an X-ray contrast agent-incorporated polymeric microparticle

被引：3

作者：

Ahn, Sungsook ^{[2
]}

Jung, Sung Yong ^{[1
]}

Lee, Jin Pyung ^{[3
]}

Lee, Sang Joon ^{[1
,2
,3
,4
]}

机构：

[1] Pohang Univ Sci & Technol, Dept Mech Engn, Pohang 790784, South Korea

[2] Pohang Univ Sci & Technol, Ctr Biofluid & Biomim Res, Pohang 790784, South Korea

[3] Pohang Univ Sci & Technol, Sch Environm Sci & Engn, Pohang 790784, South Korea

[4] Pohang Univ Sci & Technol, Sch Interdisciplinary Biosci & Bioengn, Pohang 790784, South Korea

来源：

CONTRAST MEDIA & MOLECULAR IMAGING | 2011年 / 6卷 / 06期

基金：

新加坡国家研究基金会;

关键词：

X-ray contrast agents; microparticles; Beer-Lambert-Bouguer law; X-ray imaging; imaging efficiency; hydrodynamic size (DH); FLOW; VELOCIMETRY;

D O I：

10.1002/cmmi.440

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Biocompatible polymeric encapsulants have been widely used as a delivery vehicle for a variety of drugs and imaging agents. In this study, X-ray contrast agent (iopamidol) is encapsulated into a polymeric microparticle (polyvinyl alcohol) as a particulate flow tracer in synchrotron X-ray imaging system. The physical properties of the designed microparticles are investigated and correlated with enhancement in the imaging efficiency by experimental observation and theoretical interpretation. The X-ray absorption ability of the designed microparticle is assessed by BeerLambertBouguer law. Particle size, either in dried state or in solvent, primarily dominates the X-ray absorption ability under the given condition, thus affecting imaging efficiency of the designed X-ray contrast flow tracers. Copyright (C) 2011 John Wiley & Sons, Ltd.

引用

页码：437 / 448

页数：12

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