The New Realization About Cribriform Prostate Cancer

被引：52

作者：

Iczkowski, Kenneth A. ^{[1
]}

Paner, Gladell P. ^{[2
]}

Van der Kwast, Theodorus ^{[3
]}

机构：

[1] Med Coll Wisconsin, Dept Pathol, 9200 W Wisconsin Ave, Milwaukee, WI 53226 USA

[2] Univ Chicago, Dept Pathol, 5841 S Maryland Ave, Chicago, IL 60637 USA

[3] Univ Hlth Network, Dept Pathol, Toronto, ON, Canada

来源：

ADVANCES IN ANATOMIC PATHOLOGY | 2018年 / 25卷 / 01期

关键词：

cribriform; Gleason grading; prostate cancer; PTEN; morphology; GLEASON PATTERN 4; ULTRASOUND (TRUS)-GUIDED BIOPSIES; ISUP CONSENSUS-CONFERENCE; GRADE GROUP GG; INTRADUCTAL CARCINOMA; RADICAL PROSTATECTOMY; INTERNATIONAL-SOCIETY; PROLIFERATION INDEX; SCORE; ADENOCARCINOMA;

D O I：

10.1097/PAP.0000000000000168

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Data from the past 6 years have shown that the presence of any amount of cribriform (or more comprehensively, large acinar cribriform to papillary) pattern of invasive prostate cancer is associated with adverse pathologic features and leads to uniquely adverse outcomes. Sixteen papers and numerous abstracts have reached these conclusions concordantly. Not only does this justify removal of all cribriform cancer from Gleason grade 3, it shows that cribriform cancer has pathologic, outcome, and molecular features distinct from noncribriform Gleason grade 4. Suggestions for accommodating the presence of cribriform cancer into the 2014 Grade Group scheme are proposed.

引用

页码：31 / 37

页数：7